1,4-环己二酮单乙二醇缩酮合成路线 （共 270 条）
反应条件
ammonia; hydrogen; palladium 10 on activated carbon in methanol P=3000.3 Torr;
参考文献
MOTAC NEUROSCIENCE LIMITED
Patent: WO2009/56805 A1, 2009 ;
Location in patent: Page/Page column 62; 77 ;
WO 2009/056805 A1
反应条件
1.1: magnesium sulfate / dichloromethane / 2 h / 20 °C 1.2: 4 h / 110 °C 2.1: trifluoroacetic acid / acetone / 24 h / 65 °C 3.1: sodium tetrahydroborate / methanol / 1.5 h / 0 - 20 °C / Inert atmosphere 4.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 5.1: sodium azide / 24 h 6.1: 10 palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C View Scheme
参考文献
Nirogi, Ramakrishna V. S.; Konda, Jagadishu Babu; Kambhampati, Ramasastry; Shinde, Anil; Bandyala, Thrinath Reddy; Gudla, Parandhama; Kandukuri, Kiran Kumar; Jayarajan, Pradeep; Kandikere, Vishwottam; Dubey, P. K.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 22 p. 6980 - 6985,6
反应条件
1: EtOD, Et3N / 72 h / Ambient temperature 2: LiAlD4 3: Pyridine 4: 1.) NaB(Et)3D 2.) H2O, 2 N HCl / 1.) THF 2.) THF, rt, 5 h View Scheme
参考文献
Chemische Berichte, , vol. 125, # 1 p. 209 - 215
反应条件
potassium tert-butylate in ethylene glycol dimethyl ether; ethanol 1) 0 deg C, 1 h, 2) r.t., 2 h.;
参考文献
Synthesis, , # 11 p. 1080 - 1082
反应条件
potassium tert-butylate in ethylene glycol dimethyl ether; ethanol T=0 - 20°C;
参考文献
US2005/261327 A1, ;
Page/Page column 17; 26 ;
US 20050261327 A1
反应条件
1.1: Mg / tetrahydrofuran 1.2: 77.2 percent / tetrahydrofuran / 24 h / Heating 2.1: 41 percent / trifluoroacetic acid / 0.5 h / 20 °C 3.1: 41 percent / H2 / Pd/C / ethyl acetate / 3 h / 20 °C / atmospheric pressure View Scheme
参考文献
Chu, Xin-Jie; Bartkovitz, David; Danho, Waleed; Swistok, Joseph; Cheung, Adrian Wai-Hing; Kurylko, Grazyna; Rowan, Karen; Yeon, Mitch; Franco, Lucia; Qi, Lida; Chen, Li; Yagaloff, Keith
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 22 p. 4910 - 4914
反应条件
1: 80 percent 2: 70 percent / para-toluene-sulphonic acid / toluene 3: 85 percent / H2 / Raney nickel / methanol / 82506.6 Torr 4: H2O View Scheme
参考文献
Rontani, J.-F.; Giusti, G.
Organic Mass Spectrometry, 1989 , vol. 24, p. 773 - 776
反应条件
N-methylaniline; toluene-4-sulfonic acid in toluene 30 h; Heating;
参考文献
Haga, Kazuo; Oohashi, Masayuki; Kaneko, Ryohei
Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 6 p. 1586 - 1590
反应条件
BaCl2 in water T=19.85 - 179.85°C; P=7575.61 Torr; 0.666667 h;
参考文献
Sato, Kimihiko; Kishimoto, Tsutomu; Morimoto, Minoru; Saimoto, Hiroyuki; Shigemasa, Yoshihiro
Tetrahedron Letters, 2003 , vol. 44, # 47 p. 8623 - 8625
反应条件
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 48 h / Inert atmosphere 2: pyridine; 4-(N,N-dimethlyamino)pyridine; thionyl chloride / tetrahydrofuran / 24 h / Inert atmosphere; Reflux 3: 5 platinum on carbon; hydrogen / methanol / 16 h / 760.05 Torr 4: hydrogenchloride / methanol; water / 1.5 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 76, # 19 p. 7706 - 7719
