1,4-环己二酮单乙二醇缩酮合成路线

4746-97-81,4-环己二酮单乙二醇缩酮+4210-04-2→51656-90-78-亚甲基-1,4-二噁螺[4.5]癸烷

参考文献

Alonso, Diego A.; Fuensanta, Monica; Najera, Carmen; Varea, Montserrat
Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6404 - 6416

4746-97-81,4-环己二酮单乙二醇缩酮→51656-91-82-(1,4-二氧杂螺[4.5]癸烷-8-亚基)乙酸乙酯

参考文献

Schering Corporation
Patent: US2006/264489 A1, 2006 ;
Location in patent: Page/Page column 77-78 ;

4746-97-81,4-环己二酮单乙二醇缩酮+867-13-0膦酰乙酸三乙酯→51656-91-82-(1,4-二氧杂螺[4.5]癸烷-8-亚基)乙酸乙酯

参考文献

Toyota, Masahiro; Seishi, Takashi; Yokoyama, Masaru; Fukumoto, Keiichiro; Kabuto, Chizuko
Tetrahedron, 1994 , vol. 50, # 4 p. 1093 - 1104

4746-97-81,4-环己二酮单乙二醇缩酮+1099-45-2乙氧甲酰基亚甲基三苯基膦→51656-91-82-(1,4-二氧杂螺[4.5]癸烷-8-亚基)乙酸乙酯

参考文献

Stocks, Paul A.; Bray, Patrick G.; Barton, Victoria E.; Al-Helal, Mohammed; Jones, Michael; Araujo, Nuna C.; Gibbons, Peter; Ward, Stephen A.; Hughes, Ruth H.; Biagini, Giancarlo A.; Davies, Jill; Amewu, Richard; Mercer, Amy E.; Ellis, Gemma; O'Neill, Paul M.
Angewandte Chemie - International Edition, 2007 , vol. 46, # 33 p. 6278 - 6283

4746-97-81,4-环己二酮单乙二醇缩酮→51656-91-82-(1,4-二氧杂螺[4.5]癸烷-8-亚基)乙酸乙酯

参考文献

CHISSO Corporation; CHISSO PETROCHEMICAL Corporation
Patent: US2008/63814 A1, 2008 ;

4746-97-81,4-环己二酮单乙二醇缩酮+311-46-6二甲基膦酰基乙酸乙酯→51656-91-82-(1,4-二氧杂螺[4.5]癸烷-8-亚基)乙酸乙酯

参考文献

Ciufolini; Byrne
Journal of the American Chemical Society, 1991 , vol. 113, # 21 p. 8016 - 8024

4746-97-81,4-环己二酮单乙二醇缩酮+35752-46-6→51656-91-82-(1,4-二氧杂螺[4.5]癸烷-8-亚基)乙酸乙酯

参考文献

Urrutia, Anahi; Rodriguez, J. Gonzalo
Tetrahedron Letters, 1998 , vol. 39, # 23 p. 4143 - 4146

4746-97-81,4-环己二酮单乙二醇缩酮+38868-10-9→51656-91-82-(1,4-二氧杂螺[4.5]癸烷-8-亚基)乙酸乙酯

参考文献

Inoue, Hirohumi; Murata, Shizuaki; Suzuki, Toshiyasu
Liebigs Annalen der Chemie, 1994 , # 9 p. 901 - 910

4746-97-81,4-环己二酮单乙二醇缩酮+616-38-6碳酸二甲酯→52506-21-58-氧代-1,4-二噁螺[4.5]癸烷-7-羧酸甲酯

参考文献

Su, Jing; Tang, Haiqun; McKittrick, Brian A.
Tetrahedron Letters, 2011 , vol. 52, # 26 p. 3382 - 3385

→52506-21-58-氧代-1,4-二噁螺[4.5]癸烷-7-羧酸甲酯

参考文献

Fischer, Derek; Theodorakis, Emmanuel A.
European Journal of Organic Chemistry, 2007 , # 25 p. 4193 - 4196