1,4-苯并二氧六环-2-甲酸乙酯合成路线 （共 44 条）
反应条件
potassium carbonate in acetone 5.5 h; Heating;
参考文献
Fang; Grover, Paul; Han, Zhengxu; McConville, Fran X.; Rossi, Richard F.; Olsson, Damase J.; Kessler, Donald W.; Wald, Stephen A.; Senanayake, Chris H.
Tetrahedron Asymmetry, 2001 , vol. 12, # 15 p. 2169 - 2174
反应条件
sulfuric acid; hydrazine hydrate T=80°C; 5 h;
参考文献
Yang, Yu-Shun; Li, Qing-Shan; Sun, Shuai; Zhang, Yan-Bin; Wang, Xiao-Liang; Zhang, Fei; Tang, Jian-Feng; Zhu, Hai-Liang
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 20 p. 6048 - 6058
反应条件
potassium carbonate; acetone
参考文献
Koo et al.
Journal of the American Chemical Society, 1955 , vol. 77, p. 5373
反应条件
1: 64 percent / bromine / methanol / 0 °C 2: 87 percent / potassium carbonate / acetone / Heating View Scheme
参考文献
Rouf, Abdul; Gupta, Pankaj; Aga, Mushtaq A.; Kumar, Brijesh; Chaubey, Asha; Parshad, Rajinder; Taneja, Subhash C.
Tetrahedron Asymmetry, 2012 , vol. 23, # 22-23 p. 1615 - 1623
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; Reduction; 0.5 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 35, # 7-8 p. 663 - 676
反应条件
1: 99 percent / N-bromosuccinimide, CaCO3, benzoyl peroxide / 18 h / Heating 2: 94 percent / sodium iodide / acetone / Ambient temperature 3: 91 percent / sodium hydroxide / 1.33 h / 70 - 80 °C 4: 93 percent / lithium diisopropylamide / tetrahydrofuran / -70 deg C, 2 h, then r.t. View Scheme
参考文献
Australian Journal of Chemistry, , vol. 49, # 4 p. 533 - 538
反应条件
sodium hydroxide; thionyl chloride
参考文献
Mauleon; Antunez; Rosell
Farmaco, 1989 , vol. 44, # 11 p. 1109 - 1117
参考文献
Koo et al.
Journal of the American Chemical Society, 1955 , vol. 77, p. 5373
反应条件
in water; toluene T=35°C; Substitution; 40 h;
参考文献
Sanchez, Isabel; Dolors Pujol, Maria; Guillaumet, Gerald; Massingham, Roy; Monteil, Andre; Dureng, Georges; Winslow, Eileen
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 7-8 p. 663 - 676
反应条件
1: 75 percent / toluene; H2O / 40 h / 35 °C 2: LiAlH4 / tetrahydrofuran / 24 h / 50 °C View Scheme
参考文献
Sanchez, Isabel; Dolors Pujol, Maria; Guillaumet, Gerald; Massingham, Roy; Monteil, Andre; Dureng, Georges; Winslow, Eileen
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 7-8 p. 663 - 676
