(3-甲氧基-4-甲基苯基)甲醇合成路线 （共 15 条）
反应条件
1: SOCl2 2: dimethylformamide View Scheme
参考文献
Valenta; Protiva
Collection of Czechoslovak Chemical Communications, 1977 , vol. 42, # 7 p. 2240 - 2245
反应条件
thionyl chloride; water; sodium iodide 1.) benzene, 2.5 h, 2.) ethyl methyl ketone, reflux, 3 h; Yield given. Multistep reaction;
参考文献
Kametani, Tetsuji; Kigawa, Yoshio; Nemoto, Hideo; Ihara, Masataka; Fukumoto, Keiichiro
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1607 - 1613
反应条件
Dess-Martin periodane in dichloromethane T=0°C; 0.5 h;
参考文献
ZAPAQ, INC.; THE BOARD OF TRUSTEES OF THE UNVERSITY OF ILLINOIS; OKLAHOMA MEDICAL RESEARCH FOUNDATION
Patent: WO2006/110668 A1, 2006 ;
Location in patent: Page/Page column 65 ;
WO 2006/110668 A1
反应条件
1: 80 percent / KOCl, benzyltributylammnium chloride / H2O; ethyl acetate / 0.5 h 2: 80 percent / NaOCH3 / methanol / 1) -5 deg C, 2 h, 2) room temperature, 3 h 3: 1) NaOCH3, H2O, 2) AcOH / 1) MeOH, 2) benzene, H2O, 80 deg C View Scheme
参考文献
Cannon; True; Long; Bhatnagar; Leonard; Flynn
Journal of Medicinal Chemistry, 1989 , vol. 32, # 9 p. 2210 - 2214
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=0°C; 0.5 h;
参考文献
ZAPAQ, INC.; THE BOARD OF TRUSTEES OF THE UNVERSITY OF ILLINOIS; OKLAHOMA MEDICAL RESEARCH FOUNDATION
Patent: WO2006/110668 A1, 2006 ;
Location in patent: Page/Page column 65 ;
WO 2006/110668 A1
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=0 - 22°C; 12 h;
参考文献
Majetich, George; Hicks, Rodgers; Zhang, Yong; Tian, Xinrong; Feltman, Terry Lee; Fang, Jing; Duncan Jr., Sam
Journal of Organic Chemistry, 1996 , vol. 61, # 23 p. 8169 - 8185
反应条件
sodium tetrahydroborate in methanol
参考文献
Kametani, Tetsuji; Kigawa, Yoshio; Nemoto, Hideo; Ihara, Masataka; Fukumoto, Keiichiro
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1607 - 1613
反应条件
1: 87 percent / lithium hydroxide monohydrate / tetrahydrofuran / 6 h / Heating
2: 83 percent / copper(I) iodide / methanol; dimethylformamide / 3 h / 90 °C
3: 95 percent / lithium aluminium hydride / tetrahydrofuran / 3 h / Heating
View Scheme
参考文献
Sengupta, Sujaya; Drew, Michael G. B.; Mukhopadhyay, Ranjan; Achari, Basudeb; Banerjee, Asish Kr
Journal of Organic Chemistry, 2005 , vol. 70, # 19 p. 7694 - 7700
反应条件
1: 83 percent / copper(I) iodide / methanol; dimethylformamide / 3 h / 90 °C
2: 95 percent / lithium aluminium hydride / tetrahydrofuran / 3 h / Heating
View Scheme
参考文献
Sengupta, Sujaya; Drew, Michael G. B.; Mukhopadhyay, Ranjan; Achari, Basudeb; Banerjee, Asish Kr
Journal of Organic Chemistry, 2005 , vol. 70, # 19 p. 7694 - 7700
反应条件
1: K2CO3 / acetone / 10 h / Heating
2: LiAlH4 / tetrahydrofuran / 20 °C
View Scheme
参考文献
Fuganti, Claudio; Serra, Stefano
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 22 p. 3758 - 3764
