(S)-2-氨基-4-苯基丁酸乙酯合成路线 （共 15 条）
反应条件
1: With thionyl chloride Reflux; 2: With sodium hydrogencarbonate
参考文献
Stella, Selvaraj; Chadha, Anju
Tetrahedron Asymmetry, 2010 , vol. 21, # 4 p. 457 - 460
反应条件
hydrogen; palladium on activated charcoal in ethanol P=2585.7 Torr; 48 h;
参考文献
Hoffman, Robert V.; Johnson, M. Catherine; Okonya, John F.
Tetrahedron Letters, 1998 , vol. 39, # 11 p. 1283 - 1286
参考文献
Chang, Chung-Jang
Patent: US2003/212293 A1, 2003 ;
Location in patent: Page/Page column 2 ;
反应条件
1: 60 percent / TSA / toluene / Heating 2: 60 percent / H2 / 10percent Pd-C / ethanol / 48 h / 2585.7 Torr View Scheme
参考文献
Hoffman, Robert V.; Johnson, M. Catherine; Okonya, John F.
Tetrahedron Letters, 1998 , vol. 39, # 11 p. 1283 - 1286
参考文献
USV Pharmaceutical Corporation
Patent: US4666906 A1, 1987 ;
反应条件
hydrogenchloride in diethyl ether Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Lopez, Anna; Moreno-Manas, Marcial; Pleixats, Roser; Roglans, Anna; Ezquerra, Jesus; Pedregal, Concepcion
Tetrahedron, 1996 , vol. 52, # 24 p. 8365 - 8386
反应条件
hydrogenchloride in water
参考文献
Kang, Qiang; Zhao, Zhuo-An; You, Shu-Li
Organic Letters, 2008 , vol. 10, # 10 p. 2031 - 2034
反应条件
cobalt(II) chloride T=30°C; pH=8; aq. phosphate bufferResolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Vaidya, Bhalchandra K.; Kuwar, Suyog S.; Golegaonkar, Sandeep B.; Nene, Sanjay N.
Journal of Molecular Catalysis B: Enzymatic, 2012 , vol. 74, # 3-4 p. 184 - 191
反应条件
in water; potassium carbonate; acetonitrile
参考文献
DAICEL CHEMICAL INDUSTRIES, LTD.; Tanabe Seiyaku Co., Ltd.
Patent: EP353350 A1, 1990 ;
反应条件
formic acid; tributyl-amine; palladium on activated charcoal 1.) CH2Cl2, -20 deg C, 2 h, 2.) methanol, 2 h; Yield given. Multistep reaction;
参考文献
Lehmann; Radwansky; Thomas
Archiv der Pharmazie, 1994 , vol. 327, # 11 p. 739 - 742
