N,N-二甲基甲酰胺二甲基缩醛合成路线 （共 679 条）
参考文献
ASTRAZENECA AB
Patent: US2008/9523 A1, 2008 ;
Location in patent: Page/Page column 18; 19 ;
US 20080009523 A1
参考文献
LG Life Sciences Ltd.
Patent: WO2005/40127 A1, 2005 ;
Location in patent: Page/Page column 33 ;
WO 2005/040127 A1
反应条件
pyrrolidine; hydrazine hydrate; nickel 1.) DMF, 125 deg C, 3 h; 2.) methanol, 50-60 deg C, 3 h; Yield given. Multistep reaction;
参考文献
Repke; Ferguson
Journal of Heterocyclic Chemistry, 1982 , vol. 19, # 4 p. 845 - 848
反应条件
in chloroform T=22°C; 20 h; Kinetics;
参考文献
Mulzer, Johann; Bruentrup, Gisela
Chemische Berichte, 1982 , vol. 115, # 6 p. 2057 - 2075
反应条件
sodium methylate; thiourea; methyl iodide in methanol
参考文献
SmithKline Beecham Corporation
Patent: US5670527 A1, 1997 ;
反应条件
sodium methylate; thiourea in methanol
参考文献
SmithKline Beecham Corporation
Patent: US5756499 A1, 1998 ;
反应条件
sodium methylate; thiourea; methyl iodide in methanol; water
参考文献
SmithKline Beecham Corporation
Patent: US6218537 B1, 2001 ;
反应条件
1: methylglyoxylate methanol hemiacetal; N,N-dimethyl-formamide dimethyl acetal T=80 - 109°C; 18 h; Heating / reflux; 2: thiourea in methanol T=20°C; 0.25 h; 3: methyl iodide With sodium methylate more than 3 stages;
参考文献
Laufersweiler, Matthew John; Crago Clark, Cynthia Monesa; Clark, Michael Philip; Djung, Jane Far-Jine; De, Biswanath; Natchus, Michael George
Patent: US2003/225082 A1, 2003 ;
Location in patent: Page 8-9 ;
反应条件
T=70°C; 0.0333333 h; Microwave irradiation;
参考文献
Foucourt, Alicia; Dubouilh-Benard, Carole; Chosson, Elizabeth; Corbiere, Cecile; Buquet, Catherine; Iannelli, Mauro; Leblond, Bertrand; Marsais, Francis; Besson, Thierry
Tetrahedron, 2010 , vol. 66, # 25 p. 4495 - 4502
反应条件
toluene-4-sulfonic acid 1 h; on the steam bath;
参考文献
Journal of Heterocyclic Chemistry, , vol. 24, p. 739 - 740
