1,3-二甲基-4-哌啶酮合成路线 （共 11 条）
反应条件
sodium in xylene T=60°C; 1.5 h;
参考文献
Potapov, V. M.; Gracheva, R. A.; Okulova, V. F.
Journal of Organic Chemistry USSR (English Translation), 1989 , vol. 25, # 2.2 p. 311 - 316
Zhurnal Organicheskoi Khimii, 1989 , vol. 25, # 2 p. 348 - 354
反应条件
1: 85 percent / 4 h / Ambient temperature 2: 50 percent / Na / xylene / 1.5 h / 60 °C View Scheme
参考文献
Potapov, V. M.; Gracheva, R. A.; Okulova, V. F.
Journal of Organic Chemistry USSR (English Translation), 1989 , vol. 25, # 2.2 p. 311 - 316
Zhurnal Organicheskoi Khimii, 1989 , vol. 25, # 2 p. 348 - 354
反应条件
sulfuric acid 1) Et2O, 72 h, r.t., 2) water; Yield given. Multistep reaction;
参考文献
Butz; Vilsmaier
Tetrahedron, 1993 , vol. 49, # 27 p. 6031 - 6044
反应条件
sulfuric acid 1) Et2O, 5 d, -20 deg C, 2) water; Yield given. Multistep reaction;
参考文献
Butz; Vilsmaier
Tetrahedron, 1993 , vol. 49, # 27 p. 6031 - 6044
参考文献
Nasarow; Mistrjukow
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1958 , p. 584,586; engl. Ausg. S. 565, 567
反应条件
sulfuric acid 1) Et2O, 72 h, r.t., 2) water; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Butz; Vilsmaier
Tetrahedron, 1993 , vol. 49, # 27 p. 6031 - 6044
反应条件
sulfuric acid multistep reaction; regio-, stereoselectivity; other organometallic compounds, variation of condition; Product distribution;
参考文献
Butz; Vilsmaier
Tetrahedron, 1993 , vol. 49, # 27 p. 6031 - 6044
反应条件
hydrogenchloride; sodium hydroxide in n-heptane
参考文献
Eli Lilly and Company
Patent: US5136040 A1, 1992 ;
参考文献
Sandoz Ltd.
Patent: US3954754 A1, 1976 ;
反应条件
1.1: tetrahydrofuran 2.1: ethyl acetate 2.2: (+)-diethyl ditoluyltartrate 3.1: decahydronaphthalene / Heating 4.1: n-BuLi 5.1: phenyl chloroformate 6.1: HBr; AcOH View Scheme
参考文献
Thomas, James B.; Atkinson, Robert N.; Vinson, N. Ariane; Catanzaro, Jennifer L.; Perretta, Carin L.; Fix, Scott E.; Mascarella, S. Wayne; Rothman, Richard B.; Xu, Heng; Dersch, Christina M.; Cantrell, Buddy E.; Zimmerman, Dennis M.; Carroll, F. Ivy
Journal of Medicinal Chemistry, 2003 , vol. 46, # 14 p. 3127 - 3137
