1-(4-溴-1-萘基)乙酮合成路线 (共 13 条)
反应条件
1: 94 percent / NaOCl / H2O / 4.5 h / Heating 2: 25 percent / LiAlH4 / diethyl ether / 1.) reflux, 3 h; 2.) room temperature, 14 h View Scheme
参考文献
Dixon, Elisabeth A.; Fischer, Alfred; Robinson, Frank P.
Canadian Journal of Chemistry, 1981 , vol. 59, p. 2629 - 2641
反应条件
in N,N-dimethyl-formamide
参考文献
Kim, J. M.; Pincock, J. A.
Canadian Journal of Chemistry, 1995 , vol. 73, # 6 p. 885 - 895
反应条件
pyridine; water; iodine in methanol T=30°C; other temperatures; ΔH(excit.); KineticsMechanismThermodynamic data;
参考文献
Ananthakrishnanadar, P.; Gnanasekaran, C.
Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical & Analytical, 1980 , vol. 19, # 7 p. 646 - 649
反应条件
sodium hypochlorite in water 4.5 h; Heating;
参考文献
Dixon, Elisabeth A.; Fischer, Alfred; Robinson, Frank P.
Canadian Journal of Chemistry, 1981 , vol. 59, p. 2629 - 2641
反应条件
pyridine; water; iodine in methanol T=30°C; other temperatures; ΔH(excit.); KineticsMechanismThermodynamic data;
参考文献
Ananthakrishnanadar, P.; Gnanasekaran, C.
Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical & Analytical, 1980 , vol. 19, # 7 p. 646 - 649
反应条件
1.1: iodine / 0.67 h / Inert atmosphere; Reflux 2.1: water; sodium hydroxide / 2 h / Reflux 3.1: thionyl chloride / 2 h / Inert atmosphere; Reflux 4.1: dimethylaluminum chloride / hexane; dichloromethane / 0.5 h / 0 °C / Inert atmosphere 4.2: 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Wiley, Jenny L.; Smith, Valerie J.; Chen, Jianhong; Martin, Billy R.; Huffman, John W.
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 6 p. 2067 - 2081
反应条件
AlCl3, aluminium chloride in 1,2-dichloro-ethane
T=0 - 20°C; 24 h;
参考文献
InterMune, Inc.
Patent: US2011/152246 A1, 2011 ;
Location in patent: Page/Page column 110; 111 ;
反应条件
1: With bis-triphenylphosphine-palladium(II) chloride in toluene
T=100°C; Inert atmosphere;
2: With potassium fluoride in toluene
T=20°C; 2 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BELEMA, Makonen; SRINIVASU, Pothukanuri; BENDER, John A.; LOPEZ, Omar D.; CHEN, Qi; RAMPULLA, Richard A.; GUPTA, Samayamunthula Venkata Satya Arun Kumar; MEANWELL, Nicholas A.
Patent: WO2012/21591 A1, 2012 ;
Location in patent: Page/Page column 114-115 ;
WO 2012/021591 A1
反应条件
aluminium trichloride in carbon disulfide
参考文献
Berkovic,S.
Israel Journal of Chemistry, 1963 , vol. 1, p. 1 - 11
参考文献
Jacobs et al.
Journal of Organic Chemistry, 1946 , vol. 11, p. 27,30
Full Text Show Details
Dziewonski; Sternbach
Bulletin de l'Academie Polonaise des Sciences, Serie des Sciences Chimiques, 1931 , vol. <A>, p. 59,65