1,2,3,4-四氢喹啉-2-甲酸合成路线 （共 12 条）
反应条件
sulfuric acid; dihydrogen peroxide T=120°C; 0.583333 h;
参考文献
Gracheva, I. N.; Tochilkin, A. I.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1988 , vol. 24, p. 65 - 67
Khimiya Geterotsiklicheskikh Soedinenii, 1988 , vol. 24, # 1 p. 77 - 79
反应条件
1: SOCl2 2: LiAlH4 / tetrahydrofuran 3: I2, PPh3, imidazole / toluene; acetonitrile 4: dimethylformamide 5: 12N aq. HCl View Scheme
参考文献
Katayama, Seiji; Ae, Nobuyuki; Nagata, Ryu
Tetrahedron Asymmetry, 1998 , vol. 9, # 24 p. 4295 - 4299
参考文献
Putochin
Zhurnal Obshchei Khimii, 1935 , vol. 5, p. 1176,1180
Chem. Zentralbl., 1936 , vol. 107, # I p. 3328
反应条件
thionyl chloride T=20°C;
参考文献
Kim, HyeSung; Gim, HyoJin; Yang, Mihi; Ryu, Jae-Ha; Jeon, Raok
Heterocycles, 2007 , vol. 71, # 10 p. 2131 - 2154
反应条件
1: SOCl2 View Scheme
参考文献
Katayama, Seiji; Ae, Nobuyuki; Nagata, Ryu
Tetrahedron Asymmetry, 1998 , vol. 9, # 24 p. 4295 - 4299
反应条件
sodium hydroxide in tert-butyl alcohol 24 h; Ambient temperaturepH at 9.5;
参考文献
Shuman, Robert T.; Ornstein, Paul L.; Paschal, Jonathan W.; Gesellchen, Paul D.
Journal of Organic Chemistry, 1990 , vol. 55, # 2 p. 738 - 741
反应条件
hydrogen; platinum(IV) oxide in methanol
T=20°C; 6 h;
参考文献
Guo, Tao; Gu, Huizhong; Hobbs, Doug W.; Rokosz, Laura L.; Stauffer, Tara M.; Jacob, Biji; Clader, John W.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 11 p. 3010 - 3013
反应条件
hydrogen; platinum(IV) oxide in acetic acid
T=60°C; P=3102.9 Torr; 2 h;
参考文献
Shuman, Robert T.; Ornstein, Paul L.; Paschal, Jonathan W.; Gesellchen, Paul D.
Journal of Organic Chemistry, 1990 , vol. 55, # 2 p. 738 - 741
反应条件
hydrogenchloride in water
4 h; Heating / reflux;
参考文献
Dolle, Roland E.; Chu, Guo-Hua
Patent: US2005/54630 A1, 2005 ;
Location in patent: Page/Page column 49-50 ;
US 20050054630 A1
反应条件
hydrogen; Rh/Al2O3 in methanol
T=20°C; P=37503 Torr; 22 h; Product distribution; Further Variations:Solventsreaction time;
参考文献
Fache, Fabienne
Synlett, 2004 , # 15 p. 2827 - 2829
