1,3-二甲基-1H-吡咯并[3,2-d]嘧啶-2,4(3H,5H)-二酮合成路线 （共 7 条）
反应条件
hydrogen; palladium on activated charcoal in methanol
P=760 Torr; 2 h; Ambient temperature;
参考文献
Grahner; Winiwarter; Lanzner; Muller
Journal of Medicinal Chemistry, 1994 , vol. 37, # 10 p. 1526 - 1534
反应条件
1: 73 percent / 3 h / Heating
2: 67 percent / Zn / acetic acid / 0.5 h / 85 - 95 °C
View Scheme
参考文献
Tkachenko; Tsupak; Pozharskii
Chemistry of Heterocyclic Compounds, 2000 , vol. 36, # 3 p. 307 - 310
反应条件
1: 79 percent / HNO3, H2SO4 / 0 - 5 °C
2: 66 percent / dimethylformamide / 2 h / Ambient temperature
3: 36 percent / H2 / 10percent Pd/C / methanol / 2 h / 760 Torr / Ambient temperature
View Scheme
参考文献
Grahner; Winiwarter; Lanzner; Muller
Journal of Medicinal Chemistry, 1994 , vol. 37, # 10 p. 1526 - 1534
反应条件
1: CH2=CHCH2PPh3(1+)*Br(1-) With lithium hydride in butanone
T=20°C;
2: 6-azido-1,3-dimethyl-2,4(1H,3H)pyrimidinedione 2 h; Heating;
参考文献
Abdou, Wafaa M.; Fahmy, Amin F. M.; Kamel, Azza A.
Heteroatom Chemistry, 2002 , vol. 13, # 4 p. 357 - 365
反应条件
1: 65 percent / 15percent aq. NaOH / 40 h / Heating
2: 79 percent / HNO3, H2SO4 / 0 - 5 °C
3: 66 percent / dimethylformamide / 2 h / Ambient temperature
4: 36 percent / H2 / 10percent Pd/C / methanol / 2 h / 760 Torr / Ambient temperature
View Scheme
参考文献
Grahner; Winiwarter; Lanzner; Muller
Journal of Medicinal Chemistry, 1994 , vol. 37, # 10 p. 1526 - 1534
反应条件
acetic acid; zinc
0.166667 h; Heating;
参考文献
Tsupak, E. B.; Tkachenko, Yu. N.; Pozharskii, A. F.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1994 , vol. 30, # 9 p. 1077 - 1082
Khimiya Geterotsiklicheskikh Soedinenii, 1994 , # 9 p. 1242 - 1248
反应条件
acetic acid; zinc
T=90°C; 0.5 h;
参考文献
Baraldi, Pier Giovanni; Romagnoli, Romeo; Saponaro, Giulia; Aghazadeh Tabrizi, Mojgan; Baraldi, Stefania; Pedretti, Pamela; Fusi, Camilla; Nassini, Romina; Materazzi, Serena; Geppetti, Pierangelo; Preti, Delia
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 5 p. 1690 - 1698
