(+/-)-3-苯基丁酸合成路线 （共 94 条）
反应条件
Et4Si; water; [((S)-(+)-3,5-bis(di(xylyl)phosphino)-[2.2]-paracyclophane)dipalladium] tetrachloride; toluene-4-sulfonic acid; lithium chloride in butanone T=90°C; P=22502.3 Torr; Sealed vialInert atmosphereAutoclave;
参考文献
Clarke, Matthew Lee; Konrad, Tina Marie
Patent: US2012/178963 A1, 2012 ;
Location in patent: Page/Page column 12-13 ;
反应条件
1: bromobenzene With n-butyllithium in tetrahydrofuran T=-78 - -65°C; 2: trans-crotonic acid in tetrahydrofuran
参考文献
FUJITSU LIMITED; Kamiya, Nozomu; Tomonaga, Atsushi; Sugiyama, Hajime
Patent: US2013/317110 A1, 2013 ;
Location in patent: Paragraph 0169 ;
反应条件
Fe(III)PFP(Cl); 3-chloro-benzenecarboperoxoic acid in dichloromethane T=-78°C; 0.333333 h;
参考文献
Watanabe, Yoshihito; Ishimura, Yuzuru
Journal of the American Chemical Society, 1989 , vol. 111, # 20 p. 8047 - 8049
反应条件
1: With sodium hydroxide in tert-butyl alcohol T=30°C; 0.166667 h; 2: With sodium tetrahydroborate in tert-butyl alcohol
参考文献
Cafiero, Lauren R.; Snowden, Timothy S.
Organic Letters, 2008 , vol. 10, # 17 p. 3853 - 3856
反应条件
phosphorus; hydrogen iodide
参考文献
Fort,A.W.; Leary,R.E.
Journal of the American Chemical Society, 1960 , vol. 82, p. 2494 - 2498
反应条件
in tetrahydrofuran T=-70°C;
参考文献
Aurell, Maria Jose; Domingo, Luis Ramon; Mestres, Ramon; Munos, Elena; Zaragoza, Ramon Jose
Tetrahedron, 1999 , vol. 55, # 3 p. 815 - 830
反应条件
Candida antarctica lipase B; water T=20°C; pH=7; 65 h; aq. phosphate bufferEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Deasy, Rebecca E.; Brossat, Maude; Moody, Thomas S.; Maguire, Anita R.
Tetrahedron Asymmetry, 2011 , vol. 22, # 1 p. 47 - 61
反应条件
hydrogen; triethylamine; lt;Rh(COD)(DEGPHOS)gt;BF4 in methanol P=3800 Torr; 20 h; Ambient temperatureother rhodium catalysts, other tertiary amines, other solvents; Product distribution;
参考文献
Yamamoto, Keiji; Ikeda, Kiyoshi; Yin, Leong Kwai
Journal of Organometallic Chemistry, 1989 , vol. 370, p. 319 - 332
反应条件
sodium hydroxide in methanol 1 h; Heating;
参考文献
Smonou, Ioulia; Orfanopoulos, Michael
Synthetic Communications, 1990 , vol. 20, # 9 p. 1387 - 1397
反应条件
sodium hydroxide in methanol; water Ambient temperature;
参考文献
Nagashima, Hideo; Ozaki, Nobuyasu; Washiyama, Masayoshi; Itoh, Kenji
Tetrahedron Letters, 1985 , vol. 26, # 5 p. 657 - 660
