1 -甲基- 1H-咪唑-2 -腈合成路线 （共 12 条）
反应条件
in N,N-dimethyl-formamide
T=40°C; 16 h; Yield given;
参考文献
Whitten, Jeffrey P.; McCarthy, James R.; Matthews, Donald P.
Synthesis, 1988 , # 6 p. 470 - 472
Title/Abstract Full Text Show Details
Reese, Colin B.; Pei-Zhuo, Zhang
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 19 p. 2291 - 2302
反应条件
1: in methanol
5 h;
2: With magnesium monoperoxyphthalate hexahydrate in methanol
T=0 - 20°C;
参考文献
Wyeth
Patent: US2005/75357 A1, 2005 ;
Location in patent: Page/Page column 43 ;
US 20050075357 A1
反应条件
4-(N,N-dimethlyamino)pyridine in N,N-dimethyl-formamide
T=20°C; 15 h;
参考文献
Chauviere, Gerard; Bouteille, Bernard; Enanga, Bertin; De Albuquerque, Cristina; Croft, Simon L.; Dumas, Michel; Perie, Jacques
Journal of Medicinal Chemistry, 2003 , vol. 46, # 3 p. 427 - 440
参考文献
Merrell Dow Pharmaceuticals Inc.
Patent: US5147863 A1, 1992 ;
反应条件
MMPP in methanol
T=0 - 20°C; Inert atmosphere;
参考文献
Zhang, Nan; Ayral-Kaloustian, Semiramis; Nguyen, Thai; Hernandez, Richard; Lucas, Judy; Discafani, Carolyn; Beyer, Carl
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 111 - 118
反应条件
pyridine; trichlorophosphate in toluene
2 h; Heating;
参考文献
Bakhtiar, Cuross; Smith, Edward H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 3 p. 239 - 244
反应条件
1: 84 percent / aq. NH3 / methanol / 1) 0 deg C, 2 h; 2) room temperature, overnight
2: 46 percent / POCl3, pyridine / toluene / 2 h / Heating
View Scheme
参考文献
Bakhtiar, Cuross; Smith, Edward H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 3 p. 239 - 244
反应条件
in methanol
Ambient temperatureelectrooxidation at a platinum anode vs. SCE;
参考文献
Yoshida, Kunihisa; Kitabayashi, Hirohito
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 10 p. 3693 - 3696
反应条件
n-butyllithium
1) THF, -78 deg C, 30 min, 2) THF, -78 deg C, 30 min then -78 deg C to RT, 2 h; Yield given. Multistep reaction;
参考文献
Nagasaki, Izuru; Suzuki, Yumiko; Iwamoto, Ken-Ichi; Higashino, Takeo; Miyashita, Akira
Heterocycles, 1997 , vol. 46, # 1 p. 443 - 450
反应条件
in acetonitrile
Irradiation;
参考文献
Barltrop, John A.; Day, A. Colin; Mack, Arthur G.; Shahrisa, Aziz; Wakamatsu, Shigeru
Journal of the Chemical Society, Chemical Communications, 1981 , # 12 p. 604 - 606
