3,5-二氟苯甲酸合成路线

107-31-3甲酸甲酯+455-40-33,5-二氟苯甲酸→736990-88-83,5-二氟-4-甲酰基苯甲酸

参考文献

ALMIRALL, S.A.; DRACONIS PHARMA, S.L.; LABORATORIOS DEL DR. ESTEVE, S.A.; AGUILAR, Nuria; FERNANDEZ, Joan, Carles; TERRICABRAS, Emma; CARCELLER GONZALEZ, Elena; SALAS SOLANA, Jordi
Patent: WO2013/149997 A1, 2013 ;
Location in patent: Page/Page column 97; 98 ;

455-40-33,5-二氟苯甲酸+68-12-2N,N-二甲基甲酰胺→736990-88-83,5-二氟-4-甲酰基苯甲酸

参考文献

Furmick, Julie K.; Kaneko, Ichiro; Walsh, Angela N.; Yang, Joanna; Bhogal, Jaskaran S.; Gray, Geoffrey M.; Baso, Juan C.; Browder, Drew O.; Prentice, Jessica L.S.; Montano, Luis A.; Huynh, Chanh C.; Marcus, Lisa M.; Tsosie, Dorian G.; Kwon, Jungeun S.; Quezada, Alexis; Reyes, Nicole M.; Lemming, Brittney; Saini, Puneet; vanderVaart, Arjan; Groy, Thomas L.; Marshall, Pamela A.; Jurutka, Peter W.; Wagner, Carl E.
ChemMedChem, 2012 , vol. 7, # 9 p. 1551 - 1566

455-40-33,5-二氟苯甲酸→914637-27-73-氟-5-甲氧基苄醇

参考文献

ARAGON PHARMACEUTICALS, INC.; KAHRAMAN, Mehmet; GOVEK, Steven, P.; NAGASAWA, Johnny, Y.; SMITH, Nicholas, D.
Patent: WO2011/156518 A2, 2011 ;
WO 2011/156518 A2

455-40-33,5-二氟苯甲酸→914637-33-5

参考文献

ARAGON PHARMACEUTICALS, INC.; KAHRAMAN, Mehmet; GOVEK, Steven, P.; NAGASAWA, Johnny, Y.; SMITH, Nicholas, D.
Patent: WO2011/156518 A2, 2011 ;
WO 2011/156518 A2

455-40-33,5-二氟苯甲酸→467442-12-24-甲酰基-3,5-二氟苯甲酸叔丁酯

参考文献

EXELIXIS, INC.; BOLLU, Venkataiah; BOREN, Brant, Clayton; DALGARD, Jackline, Eve; FLATT, Brenton, T.; HAQ, Nadia; HUDSON, Sarah; MOHAN, Raju; MORRISSEY, Michael; PRATT, Benjamin; WANG, Tie-lin
Patent: WO2010/93845 A1, 2010 ;
WO 2010/093845 A1

455-40-33,5-二氟苯甲酸→470458-51-63,5-二氟-N-甲基苯胺

参考文献

Florvall, Lennart; Fagervall, Ingrid; Larsson, Lars-Gunnar; Ross, Svante B.
European Journal of Medicinal Chemistry, 1999 , vol. 34, # 2 p. 137 - 151