N-苯甲酰基-2’-脱氧腺苷合成路线 （共 27 条）
反应条件
pyridine T=20°C; 2.5 h;
参考文献
EP1253154 A1, ;
Example 2 ;
反应条件
acetic acid in water 2 h; Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Reese, Colin B.; Skone, Philip A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 1263 - 1271
反应条件
pyridine; triethylamine T=20°C; 66 h;
参考文献
Lavandera, Ivan; Fernandez, Susana; Ferrero, Miguel; Gotor, Vicente
Tetrahedron, 2003 , vol. 59, # 29 p. 5449 - 5456
反应条件
1.1: 75 percent / pyridine; imidazole / 20 °C 2.1: tin tetrachloride / 1,2-dichloro-ethane / 0.17 h / 0 °C 2.2: 50 percent / 1,2-dichloro-ethane / 1 h / 0 °C 3.1: ammonia / methanol / 72 h / 20 °C 4.1: 51 percent / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 0.75 h / 20 °C View Scheme
参考文献
Gulyaeva, Irma V.; Neuvonen, Kari; Loennberg, Harri; Rodionov, Andrei A.; Shcheveleva, Elena V.; Bobkov, Georgii V.; Efimtseva, Ekaterina V.; Mikhailov, Sergey N.
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 12 p. 1849 - 1864
反应条件
sodium chloride in chloroform; N,N-dimethyl-formamide
参考文献
Komatsu, Hironori; Kouno, Toshiyuki; Tsuchiya, Katsutoshi
Patent: US2003/9028 A1, 2003 ;
参考文献
Eisenhuth, Ralf; Richert, Clemens
Journal of Organic Chemistry, 2009 , vol. 74, # 1 p. 26 - 37
反应条件
1: N,O-bis(trimethylsilyl)acetamide / acetonitrile / 1.) 22 deg C, 1 h, 2.) r.t., 87 h
2: NaHCO3 / methanol
3: imidazole / dimethylformamide
View Scheme
参考文献
Koga; Wilk; Moore; Scremin; Zhou; Beaucage
Journal of Organic Chemistry, 1995 , vol. 60, # 6 p. 1520 - 1530
