4-甲氧基-3-甲基苯乙酸合成路线 （共 15 条）
反应条件
1: 57.2 percent / trifluoroacetic acid / 3 h 2: 84.6 percent / Triton-B / methanol; dioxane / 4 h / 80 °C 3: 1.) hydrogen chloride, 2.) NaOH / 1.) ethanol, ice-salt cooling, 30 min, 2.) ethanol, reflux, 1 h View Scheme
参考文献
Wenner
Journal of Organic Chemistry, 1951 , vol. 16, p. 457,458
反应条件
1: (COCl)2; DMF / CH2Cl2 2: diethyl ether / 0 °C 3: aq. Ag2O / dioxane View Scheme
参考文献
Young, Jonathan R.; Huang, Song X.; Chen, Irene; Walsh, Thomas F.; DeVita, Robert J.; Wyvratt Jr., Matthew J.; Goulet, Mark T.; Ren, Ning; Lo, Jane; Yang, Yi Tien; Yudkovitz, Joel B.; Cheng, Kang; Smith, Roy G.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 15 p. 1723 - 1727
反应条件
1: diethyl ether / 0 °C 2: aq. Ag2O / dioxane View Scheme
参考文献
Young, Jonathan R.; Huang, Song X.; Chen, Irene; Walsh, Thomas F.; DeVita, Robert J.; Wyvratt Jr., Matthew J.; Goulet, Mark T.; Ren, Ning; Lo, Jane; Yang, Yi Tien; Yudkovitz, Joel B.; Cheng, Kang; Smith, Roy G.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 15 p. 1723 - 1727
反应条件
1: 84.6 percent / Triton-B / methanol; dioxane / 4 h / 80 °C 2: 1.) hydrogen chloride, 2.) NaOH / 1.) ethanol, ice-salt cooling, 30 min, 2.) ethanol, reflux, 1 h View Scheme
参考文献
Katagiri; Kato; Nakano
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 7 p. 2440 - 2446
参考文献
Wenner
Journal of Organic Chemistry, 1951 , vol. 16, p. 457,458
反应条件
2: methanol. KOH View Scheme
参考文献
Wenner
Journal of Organic Chemistry, 1951 , vol. 16, p. 457,458
反应条件
hydrogenchloride; sodium hydroxide 1.) ethanol, ice-salt cooling, 30 min, 2.) ethanol, reflux, 1 h; Yield given. Multistep reaction;
参考文献
Katagiri; Kato; Nakano
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 7 p. 2440 - 2446
反应条件
1: acetic acid View Scheme
参考文献
Wessely; Schinzel
Monatshefte fuer Chemie, 1953 , vol. 84, p. 969,976, 987
反应条件
sulfuric acid; palladium; acetic acid Hydrogenation.weiteres Reagens: Bromwasserstoff; Behandlung des Reaktionsprodukts mit wss. Kalilauge;
参考文献
Kindler; Metzendorf; Kwok
Chemische Berichte, 1943 , vol. 76, p. 308,314
参考文献
Wessely; Schinzel
Monatshefte fuer Chemie, 1953 , vol. 84, p. 969,976, 987
