2-(4-甲基苯基)吡啶合成路线 （共 103 条）
反应条件
1: (4-Methylphenyl)-magnesium bromide With C24H52Cl2O12P4Pd2 in tetrahydrofuran; 1,4-dioxane T=20°C; Kumada-Corriu cross-coupling reaction; 0.0833333 h; Inert atmosphere; 2: pyridin-2-yl tosylate in tetrahydrofuran; 1,4-dioxane T=80°C; Kumada-Corriu cross-coupling reaction; 24 h; Inert atmosphere; regioselective reaction;
参考文献
Ackermann, Lutz; Kapdi, Anant R.; Fenner, Sabine; Kornhaab, Christoph; Schulzke, Carola
Chemistry - A European Journal, 2011 , vol. 17, # 10 p. 2965 - 2971
反应条件
potassium carbonate in ethanol; water T=20°C; Suzuki-Miyaura coupling; 10 h;
参考文献
Sreedhar; Yada, Divya; Reddy, P. Surendra
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 14-15 p. 2823 - 2836
反应条件
potassium phosphate; XPhos Palladacycle methyl t-butyl etherate; copper diacetate; bis-(2-hydroxy-ethyl)-amine in N,N-dimethyl-formamide T=100°C; 24 h; Inert atmosphere;
参考文献
Dick, Graham R.; Woerly, Eric M.; Burke, Martin D.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 11 p. 2667 - 2672
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; potassium phosphate; palladium diacetate in neat (no solvent) T=110°C; Suzuki-Miyaura Coupling; 24 h; Schlenk techniqueInert atmosphere;
参考文献
Asachenko, Andrey F.; Sorochkina, Kristina R.; Dzhevakov, Pavel B.; Topchiy, Maxim A.; Nechaev, Mikhail S.
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 18 p. 3553 - 3557
反应条件
copper acetylacetonate; potassium tert-butylate; oxygen in toluene T=110°C; 2 h;
参考文献
Shen, Yan; Chen, Jiuxi; Liu, Miaochang; Ding, Jinchang; Gao, Wenxia; Huang, Xiaobo; Wu, Huayue
Chemical Communications, 2014 , vol. 50, # 33 p. 4292 - 4295
反应条件
1: 91 percent / K2CO3; t-Bu3P*HBF4; Pd(OAc)2 / toluene / 110 °C 2: 95 percent / HCOONH4; Pd/C / methanol / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 127, # 51 p. 18020 - 18021
反应条件
potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); C31H25F4O5P in 1,4-dioxane T=110°C; Suzuki-Miyaura cross-coupling reaction; 24 h; Inert atmosphere;
参考文献
Ackermann, Lutz; Potukuchi, Harish K.
Synlett, 2009 , # 17 p. 2852 - 2856
反应条件
hydrogen; palladium on activated charcoal in ethanol P=760 Torr; Ambient temperature;
参考文献
Terashima, Masanao; Seki, Koh-ichi; Yoshida, Chihiro; Ohkura, Kazue; Kanaoka, Yuichi
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1009 - 1015
反应条件
1: 85 percent / Et3N / toluene / 12 h / Heating 2: 82 percent / NiClCpIMes / diethyl ether / 8 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 7, # 13 p. 2519 - 2522
反应条件
Ni(PCy3)2Cl2 in tetrahydrofuran; 1-methyl-pyrrolidin-2-one T=90°C; Negishi coupling reaction; 8 h; Inert atmosphere;
参考文献
Xie, Lan-Gui; Wang, Zhong-Xia
Angewandte Chemie - International Edition, 2011 , vol. 50, # 21 p. 4901 - 4904
