2,3-二氢-1,4-苯并二噁烷-6-羧酸合成路线 （共 19 条）
反应条件
T=130°C; im Rohr; Behandeln mit Wasser;
参考文献
Fittig; Macalpine
Justus Liebigs Annalen der Chemie, 1873 , vol. 168, p. 112
反应条件
sulfuric acid Reflux;
参考文献
Du, Qian-Ru; Li, Dong-Dong; Pi, Ya-Zhou; Li, Jing-Ran; Sun, Jian; Fang, Fei; Zhong, Wei-Qing; Gong, Hai-Bin; Zhu, Hai-Liang
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 8 p. 2286 - 2297
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / -10 - 20 °C / Inert atmosphere 2: phosphorus tribromide / dichloromethane / 2 h / 0 °C View Scheme
参考文献
Marugan, Juan J.; Zheng, Wei; Motabar, Omid; Southall, Noel; Goldin, Ehud; Westbroek, Wendy; Stubblefield, Barbara K.; Sidransky, Ellen; Aungst, Ronald A.; Lea, Wendy A.; Simeonov, Anton; Leister, William; Austin, Christopher P.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 4 p. 1033 - 1058
反应条件
thionyl chloride in dichloromethane; N,N-dimethyl-formamide T=20°C; 18 h;
参考文献
TRAGEX PHARMA; HADJ-SLIMANE, Reda; GARBAY, Christiane
Patent: WO2012/156289 A1, 2012 ;
Location in patent: Page/Page column 31 ;
参考文献
Lo Monte, Fabio; Kramer, Thomas; Gu, Jiamin; Brodrecht, Martin; Pilakowski, Johannes; Fuertes, Ana; Dominguez, Juan Manuel; Plotkin, Batya; Eldar-Finkelman, Hagit; Schmidt, Boris
European Journal of Medicinal Chemistry, 2013 , vol. 61, p. 26 - 40
反应条件
sulfuric acid; sodium hydrogencarbonate in methanol
参考文献
Wyeth Holdings Corporation
Patent: EP1117659 B1, 2003 ;
Location in patent: Page 72 ;
反应条件
1.1: acetonitrile / 0.33 h / 20 °C
2.1: triethylamine / acetonitrile / 20 h / 40 °C
3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
3.2: 20 °C / Inert atmosphere
View Scheme
参考文献
Titov, Ilia Y.; Sagamanova, Irina K.; Gritsenko, Roman T.; Karmanova, Irina B.; Atamanenko, Olga P.; Semenova, Marina N.; Semenov, Victor V.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 6 p. 1578 - 1581
参考文献
Zhang, Xiao-Min; Qiu, Min; Sun, Juan; Zhang, Yan-Bin; Yang, Yu-Shun; Wang, Xiao-Liang; Tang, Jian-Feng; Zhu, Hai-Liang
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 21 p. 6518 - 6524
反应条件
1: acetic acid; sulfuric acid; nitric acid
2: Raney nickel; ethanol / Hydrogenation
View Scheme
参考文献
Heertjes et al.
Journal of the Chemical Society, 1957 , p. 3445
