2-溴-4,6-二氟苯胺合成路线 （共 10 条）
反应条件
bromine; sodium acetate in water; acetic acid
参考文献
American Cyanamid Company
Patent: US4404402 A1, 1983 ;
反应条件
bromine; acetic acid
参考文献
Roe; Little
Journal of Organic Chemistry, 1955 , vol. 20, p. 1577,1589
参考文献
BASF Corporation
Patent: US5977412 A1, 1999 ;
反应条件
1: 91 percent / Et3N / PdCl2(PPh3)2; CuI / dimethylformamide / 50 °C 2: 70 percent / TBAF / tetrahydrofuran / 20 °C 3: 58 percent / NaAuCl4*2H2O / ethanol / 16 h / 20 °C View Scheme
参考文献
Arcadi, Antonio; Bianchi, Gabriele; Marinelli, Fabio
Synthesis, 2004 , # 4 p. 610 - 618
反应条件
1: 91 percent / Pd(OAc)2, (o-Tol)3P / triethylamine; acetonitrile / Heating 2: 61 percent / (i-Bu3)AlH / tetrahydrofuran / -78 °C 3: 73 percent / H2, HRh(CO)(PPh3)3, Ph3P / toluene / 70 h / 70 °C / 15514.4 Torr View Scheme
参考文献
Dong; Busacca
Journal of Organic Chemistry, 1997 , vol. 62, # 19 p. 6464 - 6465
反应条件
1: 91 percent / Et3N / PdCl2(PPh3)2; CuI / dimethylformamide / 50 °C
2: 70 percent / TBAF / tetrahydrofuran / 20 °C
View Scheme
参考文献
Arcadi, Antonio; Bianchi, Gabriele; Marinelli, Fabio
Synthesis, 2004 , # 4 p. 610 - 618
反应条件
triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide in N,N-dimethyl-formamide
T=50°C; Sonogashira reaction;
参考文献
Arcadi, Antonio; Bianchi, Gabriele; Marinelli, Fabio
Synthesis, 2004 , # 4 p. 610 - 618
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water
T=95°C; Suzuki-coupling reaction; 12 h;
参考文献
Joe, Dae June; Wu, Chun Ji; Bok, Taekki; Lee, Eun Jung; Lee, Choong Hoon; Han, Won-Sik; Kang, Sang Ook; Lee, Bun Yeoul
Dalton Transactions, 2006 , # 33 p. 4056 - 4062
反应条件
in ethyl acetate
T=80°C; 0.5 h;
参考文献
Tsang, W. C. Peter; Zheng, Nan; Buchwald, Stephen L.
Journal of the American Chemical Society, 2005 , vol. 127, # 42 p. 14560 - 14561
反应条件
acetic anhydride in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; water
参考文献
Novartis AG
Patent: US6291523 B1, 2001 ;
