1,3-苯并二氧杂环戊烯-5-乙腈合成路线 （共 43 条）
反应条件
copper(I) bromide in tetrahydrofuran 0.5 h; Heating;
参考文献
Micale, Nicola; Zappala, Maria; Grasso, Silvana
Farmaco (Societa chimica italiana : 1989), 2002 , vol. 57, # 10 p. 853 - 859
反应条件
1: HCl / 0 °C 2: NH3 / ethanol View Scheme
参考文献
Whitlow, Marc; Adler, Marc; Davey, David; Huang, Qinglan; Koovakkat, Sunil; Parkinson, John F.; Pham, Eric; Polokoff, Mark; Xu, Wei; Yuan, Shendong; Phillips, Gary
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2505 - 2508
反应条件
phosphoric acid in ethyl acetate 1 h; Heating;
参考文献
Kamochi, Yasuko; Watanabe, Yasuo
Heterocycles, 1987 , vol. 26, # 9 p. 2385 - 2391
反应条件
(S)-pyrophosphoric acid 12 h; Ambient temperature;
参考文献
Kamochi, Yasuko; Watanabe, Yasuo
Heterocycles, 1987 , vol. 26, # 9 p. 2385 - 2391
反应条件
lithium aluminium tetrahydride; aluminium trichloride in diethyl ether 2 h;
参考文献
Roblot, F.; Hocquemiller, R.; Cave, A.
Bulletin de la Societe Chimique de France, 1990 , # 2 p. 258 - 267
参考文献
Medinger
Monatshefte fuer Chemie, 1906 , vol. 27, p. 238
Full Text Show Details
Semmler; Bartelt
Chemische Berichte, 1908 , vol. 41, p. 2752
反应条件
1: (3,4-methylenedioxy)phenylacetonitrile With hydrogenchloride in toluene T=0°C; 0.166667 h; 2: 2,4-dihydroxy-1-ethylbenzene With ZnCl2*Et2O in toluene T=0 - 20°C; 3: With water in toluene T=90°C; pH=1; 0.5 h;
参考文献
Matin, Azadeh; Gavande, Navnath; Kim, Moon S.; Yang, Nancy X.; Salam, Noeris K.; Hanrahan, Jane R.; Roubin, Rebecca H.; Hibbs, David E.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 21 p. 6835 - 6850
反应条件
1: With boron tribromide in dichloromethane T=-78 - 20°C; 2: With water in dichloromethane
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: ZnCl2, HCl gas / diethyl ether / 0 °C / overnight
2: H2O / 2 h / Heating
View Scheme
参考文献
Jain, Amolak C.; Prasad, Ashok K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 622 - 624
反应条件
hydrogenchloride; water; zinc(II) chloride in ethyl ether
Houben-Hoesch reaction;
参考文献
Mascayano, Carolina; Rezende, Marcos Caroli; Rivera, Yenifer; Espinosa, Victoria
Journal of the Chilean Chemical Society, 2011 , vol. 56, # 4 p. 935 - 937
