2,3,4,5 -四氢-1H -苯并[D]氮杂卓合成路线 （共 16 条）
反应条件
unter Druck.Hydrogenation;
参考文献
Ruggli; Staub
Helvetica Chimica Acta, 1937 , vol. 20, p. 918,924
反应条件
1: aq. NaHCO3 / tetrahydrofuran / 20 °C 2: NH4NO3; H2SO4 3: H2 / Pd/C / ethanol 4: NaOH / methanol / Heating View Scheme
参考文献
Johnson, Paul D.; Aristoff, Paul A.; Zurenko, Gary E.; Schaadt, Ronda D.; Yagi, Betty H.; Ford, Charles W.; Hamel, Judith C.; Stapert, Douglas; Moerman, Judy K.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 23 p. 4197 - 4200
反应条件
sodium hydrogencarbonate in tetrahydrofuran T=20°C;
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5273974 A1, 1993 ;
反应条件
N-ethyl-N,N-diisopropylamine in dimethyl sulfoxide T=150°C; 1 h; Microwave irradiation;
参考文献
GLAXO GROUP LIMITED; ATKINSON, Stephen John; BARKER, Michael David; CAMPBELL, Matthew; HUMPHREYS, Philip; LIDDLE, John; SHEPPARD, Robert John; WILSON, David
Patent: WO2012/52390 A1, 2012 ;
Location in patent: Page/Page column 110 ;
WO 2012/052390 A1
反应条件
1: dimethyl sulfoxide 2: tetrahydrofuran; water; methanol; dimethyl sulfoxide View Scheme
参考文献
CELLZOME AG; Glaxo Group Limited; Atkinson, Stephen John; Barker, Michael David; Campbell, Matthew; Humphreys, Philip; Liddle, John; Sheppard, Robert John; Wilson, David; Joberty, Gerard
Patent: EP2592154 A1, 2013 ;
反应条件
1: triethylamine / dichloromethane 2: nitric acid 3: hydrogenchloride / water / |Heating 4: triethylamine; 4-(N,N-dimethlyamino)pyridine / dichloromethane 5: palladium 10 on activated carbon; hydrogen / methanol View Scheme
参考文献
Urbanek, Rebecca A.; Xiong, Hui; Wu, Ye; Blackwell, William; Steelman, Gary; Rosamond, Jim; Wesolowski, Steven S.; Campbell, James B.; Zhang, Minli; Brockel, Becky; Widzowski, Daniel V.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 2 p. 543 - 547
