1,4-二氧杂螺[4.5]-2-癸酮合成路线 （共 29 条）
反应条件
1: N-bromosuccinimide, azobisisobutyronitrile / CCl4 / 0.5 h / Heating; Irradiation 2: 79 percent / toluene / 20 °C 3: 1,4-diazabicyclo<2.2.2>octane / benzene / 0.07 h / Ambient temperature 4: 65 percent / toluene / 1 h / Heating 5: magnesium / 1.) ether, 60 min, RT, 2.) 19 h View Scheme
参考文献
Ramage, Robert; Griffiths, Gareth J.; Shutt, Fiona E.; Sweeney, John N. A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 7 p. 1531 - 1537
反应条件
lithium diisopropyl amide
1.) THF, -78 deg C, 25 min, 2.) -78 deg C --> room temperature, overnight; Yield given. Multistep reaction;
参考文献
Ramage, Robert; Griffiths, Gareth J.; Shutt, Fiona E.; Sweeney, John N. A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 7 p. 1539 - 1545
反应条件
lithium diisopropyl amide
1.) THF, -78 deg C, 25 min, 2.) -78 deg C --> room temperature, overnight; Yield given. Multistep reaction;
参考文献
Ramage, Robert; Griffiths, Gareth J.; Shutt, Fiona E.; Sweeney, John N. A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 7 p. 1539 - 1545
反应条件
n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
18 h; Ambient temperature;
参考文献
Nishide; Aramata; Kamanaka; Inoue; Node
Tetrahedron, 1994 , vol. 50, # 28 p. 8337 - 8346
反应条件
1: N-bromosuccinimide, azobisisobutyronitrile / CCl4 / 0.5 h / Heating; Irradiation
2: 79 percent / toluene / 20 °C
3: 1,4-diazabicyclo<2.2.2>octane / benzene / 0.07 h / Ambient temperature
View Scheme
参考文献
Ramage, Robert; Griffiths, Gareth J.; Shutt, Fiona E.; Sweeney, John N. A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 7 p. 1531 - 1537
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane
0.5 h; HeatingIrradiation;
参考文献
Ramage, Robert; Griffiths, Gareth J.; Shutt, Fiona E.; Sweeney, John N. A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 7 p. 1531 - 1537
反应条件
1: propionic acid methyl ester With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
T=-78°C; 0.416667 h;
2: cyclohexanespiro-2'-(1',3'-dioxolan)-4'-one in tetrahydrofuran; hexane'
T=-78 - 20°C;
参考文献
Perez, Manuel; Perez, Daniel I.; Martinez, Ana; Castro, Ana; Gomez, Generosa; Fall, Yagamare
Chemical Communications, 2009 , # 22 p. 3252 - 3254
反应条件
lithium diisopropyl amide
1.) THF, -78 deg C, 25 min, 2.) -78 deg C --> room temperature, overnight; Yield given. Multistep reaction;
参考文献
Ramage, Robert; Griffiths, Gareth J.; Shutt, Fiona E.; Sweeney, John N. A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 7 p. 1539 - 1545
反应条件
lithium diisopropyl amide
1.) THF, -78 deg C, 25 min, 2.) -78 deg C --> room temperature, overnight; Yield given. Multistep reaction;
参考文献
Ramage, Robert; Griffiths, Gareth J.; Shutt, Fiona E.; Sweeney, John N. A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 7 p. 1539 - 1545
