[3-(2-氯苯基)异噁唑-5-基]甲醇合成路线 （共 7 条）
反应条件
potassium hydrogencarbonate; copper(II) sulfate; sodium L-ascorbate in water; tert-butyl alcohol T=20°C; 1.5 h;
参考文献
Wang, Xi-Zhao; Jia, Jiong; Zhang, Yan; Xu, Wei-Ren; Liu, Wei; Shi, Fang-Niu; Wang, Jian-Wu
Journal of the Chinese Chemical Society, 2007 , vol. 54, # 3 p. 643 - 652
反应条件
1: py2ald With N-chloro-succinimide in N,N-dimethyl-formamide T=0 - 60°C; 2: propargyl alcohol With triethylamine in N,N-dimethyl-formamide T=0 - 20°C; 19.5 h;
参考文献
ARRAY BIOPHARMA INC.; RODRIGUEZ, Martha, E.; MARESKA, David, A.; HANS, Jeremy, J.; HARVEY, Darren, M.; GRONEBERG, Robert, D.; O'SULLIVAN, Michael
Patent: WO2010/80864 A1, 2010 ;
Location in patent: Page/Page column 164-165 ;
反应条件
1: 2-chloro benzaldehyde oxime With N-chloro-succinimide in N,N-dimethyl-formamide 3 h; 2: propargyl alcohol With CuSO4‵5H2O; potassium carbonate; ascorbic acid powder in N,N-dimethyl-formamide 1 h;
参考文献
Yin; Jia; Zhao; Xu; Tang; Wang
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2011 , vol. 50, # 5 p. 695 - 703
反应条件
1.1: N-chlorosuccinimide / CH2Cl2 2.1: DCC; DMAP; PEG-OCOCH2CH2COOH / CH2Cl2 / 16 h / 20 °C 2.2: Et3N / CH2Cl2 / 20 °C 2.3: aq. NaOH / 3 h / 20 °C View Scheme
参考文献
Shang, Yong-Jia; Wang, Yan-Guang
Synthesis, 2002 , # 12 p. 1663 - 1668
反应条件
1.1: hydroxylamine hydrochloride; sodium carbonate / methanol; water / 4 h / 20 °C 2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h 2.2: 1 h View Scheme
参考文献
Zhang, Datong; Jia, Jiong; Meng, Lijuan; Xu, Weiren; Tang, Lida; Wang, Jianwu
Archives of Pharmacal Research, 2010 , vol. 33, # 6 p. 831 - 842
反应条件
1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.5 h / 20 °C / ultrasonic irradiation 2: triethylamine / N,N-dimethyl-formamide / 0 °C / ultrasound irradiation View Scheme
参考文献
Shen, Chuansheng; Zhang, Yumin; Gan, Yuanming; Zhao, Tianqi; Gu, Qiang
Letters in Organic Chemistry, 2011 , vol. 8, # 4 p. 278 - 281
反应条件
1: triethylamine / dichloromethane / 11 h / 0 - 20 °C
2: sodium azide / N,N-dimethyl-formamide / 8 h / 55 °C
3: water; ammonium chloride; zinc / ethanol / 0.5 h / Reflux
View Scheme
参考文献
Zhang, Datong; Jia, Jiong; Meng, Lijuan; Xu, Weiren; Tang, Lida; Wang, Jianwu
Archives of Pharmacal Research, 2010 , vol. 33, # 6 p. 831 - 842
