2-氨基-2,3-二甲基-丁酸合成路线 （共 12 条）
反应条件
hydrogen bromide in 1,4-dioxane
3 h; Heating;
参考文献
Branca, Mathieu; Gori, Didier; Guillot, Regis; Alezra, Valerie; Kouklovsky, Cyrille
Journal of the American Chemical Society, 2008 , vol. 130, # 18 p. 5864 - 5865
反应条件
1: With hydrogen bromide in water
RefluxInert atmosphere;
2: With Dowex-H+
Inert atmosphere;
参考文献
Branca, Mathieu; Pena, Sebastien; Guillot, Regis; Gori, Didier; Alezra, Valerie; Kouklovsky, Cyrille
Journal of the American Chemical Society, 2009 , vol. 131, # 30 p. 10711 - 10718
反应条件
10 Pd on charcoal; cyclohexene in ethanol
1 h; Reflux;
参考文献
Levine, Mindy; Kenesky, Craig Scott; Mazori, Daniel; Breslow, Ronald
Organic Letters, 2008 , vol. 10, # 12 p. 2433 - 2436
反应条件
in water
T=37°C; Ochrobactrum anthropi NCIMB 40321;
参考文献
Kaptein, Bernard; Monaco, Vania; Broxterman, Quirinus B.; Schoemaker, Hans E.; Kamphuis, Johan
Recueil des Travaux Chimiques des Pays-Bas, 1995 , vol. 114, # 4-5 p. 231 - 238
反应条件
1: LDA / tetrahydrofuran; hexane / 0.5 h / -78 °C
2: tetrahydrofuran; hexane / 2 h / -78 - 0 °C
3: 1.) 6 N HCl, 2.) Dowex 50 WX / 1.) water, 175 deg C to 185 deg C, 4 h; 2.) water
View Scheme
参考文献
Seebach, Dieter; Aebi, Johannes D.; Naef, Reto; Weber, Theodor
Helvetica Chimica Acta, 1985 , vol. 68, p. 144 - 154
反应条件
sodium hydroxide
(enzymatic transformation);
参考文献
Turk; Panse; Marshall
The Journal of organic chemistry, 1975 , vol. 40, # 7 p. 953 - 955
反应条件
T=37°C; Mycobacterium neoarum ATCC 25795, pH 8-8.5; Yield given;
参考文献
Kaptein; Boesten; Broxterman; Peters; Schoemaker; Kamphuis
Tetrahedron Asymmetry, 1993 , vol. 4, # 6 p. 1113 - 1116
反应条件
hydrogenchloride; Dowex 50 WX
1.) water, 175 deg C to 185 deg C, 4 h; 2.) water; Yield given. Multistep reaction;
参考文献
Seebach, Dieter; Aebi, Johannes D.; Naef, Reto; Weber, Theodor
Helvetica Chimica Acta, 1985 , vol. 68, p. 144 - 154
反应条件
1: L-methyl-Val With chloro-trimethyl-silane in dichloromethane
3 h; Inert atmosphereReflux;
2: (9H-Fluoren-9-yl)-methyl chloroformate With N-ethyl-N,N-diisopropylamine
T=0°C;
参考文献
Caporale; Gesiot; Sturlese; Wittelsberger; Mammi; Peggion
Amino Acids, 2012 , vol. 43, # 1 p. 207 - 218
反应条件
1: With sodium tetrahydroborate in tetrahydrofuran
T=0°C; 0.333333 h;
2: With sulfuric acid in tetrahydrofuran; diethyl ether
T=0°C; 4.5 h;
参考文献
MERCK SHARP andamp; DOHME CORP.; SCYNEXIS, INC.; GREENLEE, Mark, L.; WILKENING, Robert; APGAR, James; SPERBECK, Donald; WILDONGER, Kenneth, James; MENG, Dongfang; PARKER, Dann, L.; PACOFSKY, Gregory, James; HEASLEY, Brian, Haid; MAMAI, Ahmed; NELSON, Kingsley
Patent: WO2010/19204 A1, 2010 ;
Location in patent: Page/Page column 54 ;
