2-(4-溴苯基)-2-甲基-1,3-二氧戊环合成路线 （共 23 条）
反应条件
1.1: n-butyllithium / petroleum ether / 1 h / -78 °C 1.2: 35 percent / petroleum ether; diethyl ether / 1 h / -78 °C 2.1: 80 percent / pyridinium chlorochromate / CH2Cl2 / 0 - 20 °C View Scheme
参考文献
Bhanthumnavin; Bentrude
Journal of Organic Chemistry, 2001 , vol. 66, # 3 p. 980 - 990
反应条件
1: With 9-bora-bicyclo[3.3.1]nonane in toluene 18 h; Inert atmosphereReflux; 2: With dihydrogen peroxide; sodium hydroxide in ethanol; water T=20°C; 2 h; Inert atmosphereReflux;
参考文献
Soderquist, John A.; Kock, Iveliz; Estrella, Maria E.
Organic Process Research and Development, 2006 , vol. 10, # 5 p. 1076 - 1079
反应条件
1: p-bromo-(2'-methyl-1',3'-dioxolan-2'-yl)-benzene With n-butyllithium in diethyl ether; hexane T=-30 - -20°C; Metallation; 2 h; 2: N,N-dimethyl-formamide in diethyl ether; hexane T=-20°C; Substitution; 0.25 h;
参考文献
Meier, Herbert; Aust, Harald; Ickenroth, Dirk; Kolshorn, Heinz
Journal fuer Praktische Chemie - Practical Applications and Applied Chemistry (Germany), 1999 , vol. 341, # 6 p. 529 - 535
反应条件
in tetrahydrofuran; hexane; N,N-dimethyl-formamide
参考文献
ZENECA LIMITED; ZENECA Pharma S.A.
Patent: EP581464 A1, 1994 ;
EP 0581464 A1
反应条件
Multistep reaction.;
参考文献
Spivey, Alan C.; Srikaran, Ratnasothy; Diaper, Christopher M.; Turner, David J.
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 10 p. 1638 - 1640
反应条件
n-butyllithium; iodine in tetrahydrofuran T=-78°C;
参考文献
Charbonnel-Jobic, Gaelle; Guemas, Jean-Pierre; Adelaere, Bruno; Parrain, Jean-Luc; Quintard, Jean-Paul
Bulletin de la Societe Chimique de France, 1995 , vol. 132, p. 624 - 636
反应条件
diiodo monosilane in chloroform T=-42°C; 0.0166667 h; other reagent: iodotrimethylsilane (TMSI); other temp. and mol percent; other ketals and acetals;
参考文献
Keinan, E.; Perez, D.; Sahai, M.; Shvily, R.
Journal of Organic Chemistry, 1990 , vol. 55, # 9 p. 2927 - 2938
反应条件
NaH-t-AmONa-Ni(OAc)2-bpy-KI 1.) benzene/THF, 63 deg C, 2.5 h; Yield given. Multistep reaction;
参考文献
Lourak, Mouhsine; Vanderesse, Regis; Fort, Yves; Caubere, Paul
Journal of Organic Chemistry, 1989 , vol. 54, # 20 p. 4840 - 4844
反应条件
1: 1) n-butyllithium / 1) ether, -30 deg C, 2 h, 2) -40 deg C 2: 64 percent / CH3ONa / methanol / 84 h / -10 °C 3: 78 percent / xylene / 2 h / Heating 4: 93 percent / HCl conc. / ethanol / 1 h / Ambient temperature 5: 97 percent / aq. KOH / 3 h / Heating 6: 77 percent / copper chromite (barium promoted) / quinoline / 3 h / 220 °C View Scheme
参考文献
Kim, Phieo Ta; Guilard, Roger; Dodey, Pierre; Sornay, Roland
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 1365 - 1371
反应条件
(i) Mg, THF, (ii) /BRN= 1900390/; Multistep reaction;
参考文献
Feugeas,C.
Bulletin de la Societe Chimique de France, 1963 , p. 2579 - 2581
