反应条件
1: 84 percent / LiAlH4 / diethyl ether / 7 h / Heating 2: 69 percent / pyridinium chlorochromate / CH2Cl2 / 1.5 h / Ambient temperature 3: 1.) Zn, PPh3 / 1.) CH2Cl2, RT, 72 h, 2.) CH2Cl2, RT, 96 h 4: 1.) MeLi / 1.) THF, Et2O, a) -78 deg C, 1 h, b) RT, 3 h, 2.) THF, Et2O, RT, 17 h 5: 1.) CuI / 1.) THF, Et2O, from -10 deg C to 0 deg C, 2.) THF, Et2O, -78 deg C, 7.5 h 6: LiAlH4 / diethyl ether / 6 h / Ambient temperature View Scheme
参考文献
Argenti; Bellina; Carpita; Dell'Amico; Rossi
Synthetic Communications, 1994 , vol. 24, # 22 p. 3167 - 3188
