2-环己基-2-羟基苯乙酸合成路线 （共 28 条）
反应条件
sodium hydroxide; water in methanol T=80°C; 3.5 h;
参考文献
NEKTAR THERAPEUTICS AL, CORPORATION
Patent: WO2008/112261 A1, 2008 ;
Location in patent: Page/Page column 38 ;
反应条件
1: With methanol; water; sodium hydroxide 2 h; Reflux; 2: With hydrogenchloride; water T=0°C; pH=3 - 4;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2009/247628 A1, 2009 ;
Location in patent: Page/Page column 53 ;
US 20090247628 A1
反应条件
hydrogen; palladium on activated charcoal in methanol T=25 - 30°C; P=1545.15 Torr; 13 h;
参考文献
SUMIKA FINE CHEMICALS Co., Ltd.
Patent: EP1205464 A2, 2002 ;
Location in patent: Example 8 ;
反应条件
1: With hydrogen; palladium on activated charcoal in methanol P=2625.26 Torr; 8 h; 2: With sodium hydroxide in water T=75 - 80°C; 4 h; 3: With hydrogenchloride in water T=60 - 70°C; pH=1;
参考文献
SUMIKA FINE CHEMICALS Co., Ltd.
Patent: EP1205464 A2, 2002 ;
Location in patent: Example 4 ;
反应条件
sodium hydroxide; palladium monocarbide in methanol; hydrogen; toluene
参考文献
Sumika Fine Chemicals Co., Ltd.
Patent: US2003/13911 A1, 2003 ;
反应条件
hydrogenchloride; sodium hydroxide; palladium monocarbide; titanium tetrachloride in methanol; water; hydrogen; chlorobenzene; toluene; cyclohexene
参考文献
Sumika Fine Chemicals Co., Ltd.
Patent: US2003/13911 A1, 2003 ;
反应条件
ammonium hydroxide; sodium hydroxide; sulfuric acid; hydrogen; palladium monocarbide in water; toluene
参考文献
Sumika Fine Chemicals Co., Ltd.
Patent: US2003/13911 A1, 2003 ;
反应条件
acetic acid; platinum Hydrogenation;
参考文献
Xu, Rong; Sim, Meng-Kwoon; Go, Mei-Lin
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 2 p. 231 - 241
反应条件
1: tetrahydrofuran / 0 - 20 °C 2: KOH / methanol / 20 °C View Scheme
参考文献
Adlerova,E. et al.
Collection of Czechoslovak Chemical Communications, 1964 , vol. 29, p. 97 - 120
反应条件
1: tetrahydrofuran / 0 - 20 °C 2: KOH / methanol / 20 °C View Scheme
参考文献
Adlerova,E. et al.
Collection of Czechoslovak Chemical Communications, 1964 , vol. 29, p. 97 - 120
