4-溴-2-甲氧基苯甲醛合成路线 （共 19 条）
反应条件
pyridinium chlorochromate in dichloromethane 4 h; Inert atmosphere;
参考文献
Chang, Yuan Jay; Chow, Tahsin J.
Journal of Materials Chemistry, 2011 , vol. 21, # 26 p. 9523 - 9531
反应条件
1: With formic acid; water; nickel-aluminum alloy T=80°C; 6 h; 2: With sodium hydrogencarbonate in water; ethyl acetate
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/7018 A1, 2007 ;
Location in patent: Page/Page column 48 ;
WO 2007/007018 A1
反应条件
potassium carbonate in acetone 0.75 h; Heating;
参考文献
Tromelin; Demerseman; Royer; et al.
European Journal of Medicinal Chemistry, 1986 , vol. 21, # 5 p. 397 - 402
反应条件
aluminum oxide; potassium fluoride in 1,4-dioxane; dimethyl sulfoxide
参考文献
Glennon, Richard A.; Raghupathi, Reva; Bartyzel, Piotr; Teitler, Milt; Leonhardt, Sigrun
Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 734 - 740
反应条件
1: 1,4-dibromo-2-methoxybenzene With n-butyllithium in diethyl ether T=-78°C; 0.25 h; 2: N,N-dimethyl-formamide in diethyl ether T=-78°C; 0.25 h;
参考文献
Dabrowski, Marek; Kubicka, Joanna; Lulinski, Sergiusz; Serwatowski, Janusz
Tetrahedron, 2005 , vol. 61, # 27 p. 6590 - 6595
反应条件
potassium carbonate T=50°C;
参考文献
ALBEMARLE CORPORATION; GIARD, Thierry, J.; MUTTERER, Vincent, L.; DURVAUX, Christophe
Patent: WO2012/9173 A1, 2012 ;
Location in patent: Page/Page column 4 ;
反应条件
1: With titanium tetrachloride in dichloromethane T=0 - 20°C; 1.25 h; 2: With hydrogenchloride in dichloromethane Further stages. Title compound not separated from byproducts.;
参考文献
Moorthy, Jarugu Narasimha; Samanta, Subhas
Journal of Organic Chemistry, 2007 , vol. 72, # 25 p. 9786 - 9789
反应条件
1: 23 percent / AlCl3, LiAlH4 / diethyl ether / 18 h / Heating 2: 35 percent / pyridinium dichromate / CH2Cl2 / 65 h / Ambient temperature View Scheme
参考文献
Williams, John D.; Khan, Atiyya R.; Cardinale, Steven C.; Butler, Michelle M.; Bowlin, Terry L.; Peet, Norton P.
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 419 - 434
反应条件
1: 1.) aq. NaOH, 3.) NaHSO3, 4.) 0.5 N HCl 2: 50 percent / K2CO3 / acetone / 48 h / Heating View Scheme
参考文献
Glennon, Richard A.; McKenney, J. D.; Lyon, Robert A.; Titeler, Milt
Journal of Medicinal Chemistry, 1986 , vol. 29, # 2 p. 194 - 199
反应条件
1: 1) TiCl4 2) AcCl3 / 2) CH2Cl2, 20 deg C, 4 h 2: 100 percent / K2CO3 / acetone / 0.75 h / Heating View Scheme
参考文献
Tromelin; Demerseman; Royer; et al.
European Journal of Medicinal Chemistry, 1986 , vol. 21, # 5 p. 397 - 402
