3-溴-1,1,1-三氟丙酮合成路线 （共 31 条）
反应条件
18 h; Heating / reflux;
参考文献
SmithKline Beecham Corporation
Patent: EP1218005 B1, 2004 ;
Location in patent: Page 25 ;
反应条件
in ethanol 6 h; Heating;
参考文献
Tanaka, Kiyoshi; Nomura, Kazuto; Oda, Hitoshi; Yoshida, Shouhei; Mitsuhashi, Keiryo
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 4 p. 907 - 911
反应条件
in diethylene glycol dimethyl ether
T=140°C; 8 h;
参考文献
Kameswaran, Venkataraman; Jiang, Biao
Synthesis, 1997 , # 5 p. 530 - 532
反应条件
baker's yeast in water
T=32°C; 4 h;
参考文献
Bucciarelli, Maria; Forni. Arrigo; Moretti, Irene; Torre, Giovanni
Synthesis, 1983 , # 11 p. 897 - 899
反应条件
(+)-Ipc2BCl; bis-(2-hydroxy-ethyl)-amine
1.) Et2O, -25 deg C, 96 h, 2.) r.t., 2 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Ramachandran, P. Veeraraghavan; Gong, Baoqing; Brown, Herbert C.
Journal of Organic Chemistry, 1995 , vol. 60, # 1 p. 41 - 46
反应条件
titanium(IV) isopropylate; triphenylphosphine
T=80°C; 24 h;
参考文献
Shen, Yanchang; Zhang, Yuming; Zhou, Yuefen
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 12 p. 1759 - 1763
反应条件
in tetrachloromethane
24 h;
参考文献
Wheelock; Severson; Hammock
Chemical Research in Toxicology, 2001 , vol. 14, # 12 p. 1563 - 1572
反应条件
in tetrachloromethane
24 h;
参考文献
Wheelock; Severson; Hammock
Chemical Research in Toxicology, 2001 , vol. 14, # 12 p. 1563 - 1572
反应条件
1: 4-(4-Methylamino-3-nitro-phenoxy)-pyridine-2-carbonitrile With sodium methylate in isopropyl alcohol
T=50°C; 1 h;
2: 3-bromo-1,1,1-trifluoroacetone With ammonium acetate in isopropyl alcohol
T=70 - 85°C; 21 h; Product distribution / selectivity;
参考文献
Novartis AG
Patent: US2007/49622 A1, 2007 ;
Location in patent: Page/Page column 42 ;
反应条件
hydrogenchloride; water
T=90°C; 24 h;
参考文献
CARDIOME PHARMA CORPORATION
Patent: WO2005/34837 A2, 2005 ;
Location in patent: Page/Page column 43 ;
WO 2005/034837 A2
