2-氧代-6-苯基-1,2-二氢-3-吡啶甲腈合成路线 （共 14 条）
反应条件
sodium methylate in acetonitrile T=80°C;
参考文献
Wang, Ning-Yu; Zuo, Wei-Qiong; Xu, Ying; Gao, Chao; Zeng, Xiu-Xiu; Zhang, Li-Dan; You, Xin-Yu; Peng, Cui-Ting; Shen, Yang; Yang, Sheng-Yong; Wei, Yu-Quan; Yu, Luo-Ting
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 6 p. 1581 - 1588
反应条件
sodium methylate 1.) acetonitrile, reflux, 12 h, 2.) DMF, 100 deg C, 5 h; Yield given. Multistep reaction;
参考文献
Zeneca Limited
Patent: US5521179 A1, 1996 ;
反应条件
copper in quinoline 4 h; Heating;
参考文献
Mosti; Menozzi; Schenone; Dorigo; Gaion; Benetollo; Bombieri
European Journal of Medicinal Chemistry, 1989 , vol. 24, # 5 p. 517 - 529
反应条件
water; sodium acetate 0.5 h; Reflux;
参考文献
Alnajjar, Abdul-Aziz; Abdelkhalik, Mervat Mohammed; Al-Enezi, Amal; Elnagdi, Mohamed Hilmy
Molecules, 2009 , vol. 14, # 1 p. 68 - 77
反应条件
sodium ethanolate in ethanol 3 h; Heating;
参考文献
Al-Omran, Fatima; Al-Awadhi, Nouria; Khalik, Mervat Mohammed Abdel; Kaul, Kamini; EL-Khair, Adel Abu; Elnagdi, Mohammed Hilmy
Journal of Chemical Research, Miniprint, 1997 , # 3 p. 601 - 615
反应条件
piperidinium acetate in water Cycloaddition; 0.166667 h; Heating;
参考文献
Hussain, Badria A.; Attia, Adel M.; Elgemeie, Galal E. H.
Nucleosides and Nucleotides, 1999 , vol. 18, # 10 p. 2335 - 2343
反应条件
1: 12 h / Heating 2: NaOMe / acetonitrile / 80 °C View Scheme
参考文献
Wang, Ning-Yu; Zuo, Wei-Qiong; Xu, Ying; Gao, Chao; Zeng, Xiu-Xiu; Zhang, Li-Dan; You, Xin-Yu; Peng, Cui-Ting; Shen, Yang; Yang, Sheng-Yong; Wei, Yu-Quan; Yu, Luo-Ting
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 6 p. 1581 - 1588
反应条件
1: 69 percent / NaOEt / ethanol / 24 h / Ambient temperature 2: 98 percent / KOH / aq. ethanol / 12 h / Heating 3: 58 percent / copper powder / quinoline / 4 h / Heating View Scheme
参考文献
Mosti; Menozzi; Schenone; Dorigo; Gaion; Benetollo; Bombieri
European Journal of Medicinal Chemistry, 1989 , vol. 24, # 5 p. 517 - 529
反应条件
1: 98 percent / KOH / aq. ethanol / 12 h / Heating 2: 58 percent / copper powder / quinoline / 4 h / Heating View Scheme
参考文献
Mosti; Menozzi; Schenone; Dorigo; Gaion; Benetollo; Bombieri
European Journal of Medicinal Chemistry, 1989 , vol. 24, # 5 p. 517 - 529
反应条件
sodium hydride Multistep reaction;
参考文献
Cyranski, Michal K.; Mieczkowski, Jozef
Acta Crystallographica Section C: Crystal Structure Communications, 1998 , vol. 54, # 10 p. 1521 - 1523
