2-氨基-4-甲氧基苯甲酸合成路线 （共 38 条）
反应条件
copper; potassium carbonate; copper(l) chloride weiteres Reagens: Isopentylalkohol;
参考文献
Brockmann et al.
Chemische Berichte, 1956 , vol. 89, p. 2174,2178
反应条件
1: 55 percent / POCl3 / 2 h / Heating 2: 50 percent / NH3; phenol / 4 h / 125 - 130 °C View Scheme
参考文献
Recanatini, Maurizio; Cavalli, Andrea; Belluti, Federica; Piazzi, Lorna; Rampa, Angela; Bisi, Alessandra; Gobbi, Silvia; Valenti, Piero; Andrisano, Vincenza; Bartolini, Manuela; Cavrini, Vanni
Journal of Medicinal Chemistry, 2000 , vol. 43, # 10 p. 2007 - 2018
反应条件
borane-THF in tetrahydrofuran T=0 - 20°C; 1.66667 h; Inert atmosphere;
参考文献
Ida, Yoshihiro; Matsubara, Ayaka; Nemoto, Toru; Saito, Manabu; Hirayama, Shigeto; Fujii, Hideaki; Nagase, Hiroshi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 19 p. 5810 - 5831
反应条件
(i) aq. H2SO4, NaNO2, (ii) KI; Multistep reaction;
参考文献
Koizumi,J. et al.
Chemical and Pharmaceutical Bulletin, 1964 , vol. 12, # 6 p. 696 - 705
反应条件
hydrogenchloride Heating;
参考文献
Booker-Milburn, Kevin I.; Dunkin, Ian R.; Kelly, Frances C.; Khalaf, Abedawn I.; Learmonth, David A.; Proctor, George R.; Scopes, David I. C.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 21 p. 3261 - 3273
反应条件
in tetrahydrofuran T=0 - 20°C; 2 h;
参考文献
Cheng, Ran; Guo, Tianjian; Zhang-Negrerie, Daisy; Du, Yunfei; Zhao, Kang
Synthesis (Germany), 2013 , vol. 45, # 21 art. no. SS-2013-H0422-OP, p. 2998 - 3006
反应条件
in ethanol T=120°C; 0.666667 h; Microwave irradiation;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 17 p. 4963 - 4966
参考文献
Chapman; Gibson; Mann
Journal of the Chemical Society, 1947 , p. 890,894
反应条件
1: acetic acid 2: aq. NaOH solution 3: POCl3; PCl5 View Scheme
参考文献
Journal of the Chemical Society, , p. 890,894
反应条件
bromine; acetic acid T=20 - 40°C; 18 h;
参考文献
Gruenenthal GmbH
Patent: US2009/69320 A1, 2009 ;
Location in patent: Page/Page column 68 ;
