4-(4-氟-苯基)-吗啉合成路线 （共 14 条）
反应条件
1: 4-(4-fluorophenyl)morpholine With HASPO; Ni(acac)2 in tetrahydrofuran T=20°C; 0.0833333 h; 2: phenyl-magnesium chloride in tetrahydrofuran T=20°C; Kumada cross-coupling; 24 h;
参考文献
Ackermann, Lutz; Born, Robert; Spatz, Julia H.; Meyer, Daniel
Angewandte Chemie - International Edition, 2005 , vol. 44, # 44 p. 7216 - 7219
反应条件
C42H44Cl3N3Pd; potassium tert-butylate in 1,4-dioxane
T=80°C; 24 h; Inert atmosphere;
参考文献
Tu, Tao; Fang, Weiwei; Jiang, Jian
Chemical Communications, 2011 , vol. 47, # 45 p. 12358 - 12360
反应条件
sodium t-butanolate; tris(dibenzylideneacetone)dipalladium (0) in toluene
T=23°C; Hartwig-Buchwald coupling;
参考文献
Hill, Lensey L.; Smith, Joanna M.; Brown, William S.; Moore, Lucas R.; Guevera, Paul; Pair, Emily S.; Porter, Jake; Chou, Joe; Wolterman, Christopher J.; Craciun, Raluca; Dixon, David A.; Shaughnessy, Kevin H.
Tetrahedron, 2008 , vol. 64, # 29 p. 6920 - 6934
反应条件
copper acetylacetonate; oxygen; benzoic acid in acetonitrile
T=50°C; 12 h;
参考文献
Zhou, Yanping; Xie, Yinjun; Yang, Lei; Xie, Pan; Huang, Hanmin
Tetrahedron Letters, 2013 , vol. 54, # 21 p. 2713 - 2716
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; [Ni0(1,5-cyclooctadiene)2]; sodium t-butanolate in toluene
T=20 - 105°C; Inert atmosphere;
参考文献
Ackermann, Lutz; Sandmann, Rene; Song, Weifeng
Organic Letters, 2011 , vol. 13, # 7 p. 1784 - 1786
反应条件
NiCl(1-naphthyl)(PPh3)2; sodium hydride; 1,3-bis(2,6-diisopropylphenyl)imidazolinium chloride in 1,4-dioxane
T=110°C; Inert atmosphere;
参考文献
Huang, Jin-Hua; Yang, Lian-Ming
Organic Letters, 2011 , vol. 13, # 14 p. 3750 - 3753
反应条件
NHC-Pd(II)-Im; potassium tert-butylate in tetrahydrofuran
T=20°C; 6 h; Inert atmosphere;
参考文献
Chen, Wen-Xin; Shao, Li-Xiong
Journal of Organic Chemistry, 2012 , vol. 77, # 20 p. 9236 - 9239,4
Title/Abstract Full Text Show Details
Chen, Wen-Xin; Shao, Li-Xiong
Journal of Organic Chemistry, 2012 , vol. 77, # 20 p. 9236 - 9239
反应条件
1: 4-fluoro-1-iodobenzene With iso-propylmagnesium bromide in tetrahydrofuran
T=-35°C; 1 h;
2: With zinc(II) chloride in tetrahydrofuran
T=-35°C; 0.166667 h;
3: morpholino benzoate With copper (I) trifluoromethane sulfonate benzene in tetrahydrofuran
T=20°C; 1 h;
参考文献
Herman, Ashley M.; Johnson, Jeffrey S.
Journal of Organic Chemistry, 2006 , vol. 71, # 1 p. 219 - 224
反应条件
bis(1,5-cyclooctadiene)nickel (0); Ipr.HCl; sodium t-butanolate in 1,4-dioxane
T=25°C; 5 h; Molecular sieveSchlenk technique; Temperature;
参考文献
Zhang, Xue-Qi; Wang, Zhong-Xia
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 9 p. 1448 - 1453
反应条件
1,2-ethanedione dioxime; tetrabutylammomium bromide; copper(I) bromide; sodium hydroxide in water
T=100°C; 24 h; Inert atmospheresealed tube;
参考文献
Li, Xufeng; Yang, Daoshan; Jiang, Yuyang; Fu, Hua
Green Chemistry, 2010 , vol. 12, # 6 p. 1097 - 1105
