5-氰基-5H-二苯并[b,f]氮杂卓合成路线 （共 9 条）
反应条件
bis(trichloromethyl) carbonate in toluene 5 h; Reflux; Product distribution / selectivity;
参考文献
Zhejiang University Of Technology; Zhejiang Jiuzhou Pharmaceutical Co., Ltd.
Patent: EP2311813 A1, 2011 ;
Location in patent: Page/Page column 3 ;
反应条件
1: With bromocyane; tris-(dimethylamino)-phosphine in 1,2-dichloro-ethane T=40 - 50°C; 7 - 8 h; 2: With sodium hydroxide in water; 1,2-dichloro-ethane 3: in water
参考文献
JUBILANT ORGANOSYS LIMITED
Patent: WO2008/12837 A1, 2008 ;
Location in patent: Page/Page column 10; 13 ;
反应条件
sodium hydroxide in dichloromethane; N,N-dimethyl acetamide; water; isopropyl alcohol
参考文献
Ciba-Geigy Corporation
Patent: US4436660 A1, 1984 ;
反应条件
sodium hydroxide in water; 1,2-dichloro-ethane; isopropyl alcohol; cyanogen chloride
参考文献
Ciba-Geigy Corporation
Patent: US4436660 A1, 1984 ;
反应条件
in chloroform 0.5 h; cooling;
参考文献
Ahmad, S. Salman; Hafeez, Farrukh; Haider, S. Imtiaz; Mahmood, Tariq
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, p. 583
反应条件
hydrogenchloride T=100°C; 1 h; Yield given;
参考文献
Ciba-Geigy Corporation
Patent: US4436660 A1, 1984 ;
反应条件
anhydrous sodium hydrogen carbonate in methanol; water
参考文献
Ciba-Geigy Corporation
Patent: US4436660 A1, 1984 ;
反应条件
in isopropyl alcohol; toluene
参考文献
Ciba-Geigy Corporation
Patent: US4452738 A1, 1984 ;
反应条件
acetic anhydride; acetic acid; sodium nitrite in ice-water; ethanol; water
参考文献
Ciba-Geigy Corporation
Patent: US4452738 A1, 1984 ;
