(4-甲基-吡啶-2-基)-甲醇合成路线 （共 14 条）
反应条件
1: With thionyl chloride in dichloromethane 0.0833333 h; Heating / reflux; 2: With sodium hydrogencarbonate in diethyl ether; water
参考文献
Eisai RandD Management Co., Ltd.
Patent: US2007/105904 A1, 2007 ;
Location in patent: Page/Page column 62 ;
反应条件
selenium(IV) oxide in 1,4-dioxane T=100°C; 3 h;
参考文献
Comba, Peter; Morgen, Michael; Wadepohl, Hubert
Inorganic Chemistry, 2013 , vol. 52, # 11 p. 6481 - 6501
反应条件
methanol; sodium hydroxide; water
T=60°C; 0.166667 h;
参考文献
Eisai RandD Management Co., Ltd.
Patent: US2007/105904 A1, 2007 ;
Location in patent: Page/Page column 62 ;
反应条件
1: With n-butyllithium in tetrahydrofuran; hexanes
T=-70°C; 1 h;
2: With oxygen in tetrahydrofuran; hexanes
T=-70°C; 1 h;
参考文献
AstraZeneca AB
Patent: US7081461 B1, 2006 ;
Location in patent: Page/Page column 44 ;
US 7081461 B1
反应条件
trifluoroacetic anhydride in dichloromethane
T=20°C; 84 h;
参考文献
Comba, Peter; Morgen, Michael; Wadepohl, Hubert
Inorganic Chemistry, 2013 , vol. 52, # 11 p. 6481 - 6501
反应条件
hydrogenchloride; ammonium hydroxide; (NH4)2S2O8 in methanol; dichloromethane; water
参考文献
Pharmacia and Upjohn Company
Patent: US6043248 A1, 2000 ;
反应条件
1: With sodium tetrahydroborate in methanol
T=20°C; 36 h; Inert atmosphere;
2: With hydrogenchloride in methanol; water
0.5 h; Inert atmosphere;
参考文献
Prat, Irene; Font, David; Company, Anna; Junge, Kathrin; Ribas, Xavi; Beller, Matthias; Costas, Miquel
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 5 p. 947 - 956
反应条件
1: CH2Cl2 / 1.5 h / Ambient temperature
2: aq. (NH4)2S2O8 / 1 h / Heating
View Scheme
参考文献
Katz, R B; Mistry, J; Mitchell, M B
Synthetic Communications, 1989 , vol. 19, # 1, 2 p. 317 - 326
反应条件
1.1: water; potassium hydroxide / 1 h / |Reflux
2.1: thionyl chloride / 16 h / |Reflux
3.1: sodium tetrahydroborate / methanol / 36 h / 20 °C / |Inert atmosphere
3.2: 0.5 h / |Inert atmosphere
View Scheme
参考文献
Prat, Irene; Font, David; Company, Anna; Junge, Kathrin; Ribas, Xavi; Beller, Matthias; Costas, Miquel
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 5 p. 947 - 956
反应条件
1.1: thionyl chloride / 16 h / |Reflux
2.1: sodium tetrahydroborate / methanol / 36 h / 20 °C / |Inert atmosphere
2.2: 0.5 h / |Inert atmosphere
View Scheme
参考文献
Prat, Irene; Font, David; Company, Anna; Junge, Kathrin; Ribas, Xavi; Beller, Matthias; Costas, Miquel
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 5 p. 947 - 956
