乙基5-(4-甲基苯基)-5-氧代戊酸酯合成路线 （共 7 条）
反应条件
copper(I) bromide; lithium bromide in tetrahydrofuran T=0°C; 18 h; Inert atmosphere;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; EBEL, Heiner; FRATTINI, Sara; GIOVANNINI, Riccardo; HOENKE, Christoph; SCHEUERER, Stefan
Patent: WO2011/151251 A1, 2011 ;
Location in patent: Page/Page column 73 ;
WO 2011/151251 A1
反应条件
toluene-4-sulfonic acid in water; toluene 8 h; Dean-StarkReflux;
参考文献
Stevanovic, Dragana; Pejovic, Anka; Damljanovic, Ivan S.; Vukicevic, Mirjana D.; Dobrikov, Georgi; Dimitrov, Vladimir; Denic, Marija S.; Radulovic, Niko S.; Vukicevic, Rastko D.
Helvetica Chimica Acta, 2013 , vol. 96, # 6 p. 1103 - 1110
反应条件
1: NaH / dimethylformamide 2: H2 / Raney-Ni / aq. ethanol View Scheme
参考文献
Severin,T.; Braeutigam,I.
Chemische Berichte, 1979 , vol. 112, p. 3007 - 3012
反应条件
1: AlCl3, aluminium chloride 2: toluene-4-sulfonic acid / toluene; water / 8 h / |Dean-Stark; |Reflux View Scheme
参考文献
Stevanovic, Dragana; Pejovic, Anka; Damljanovic, Ivan S.; Vukicevic, Mirjana D.; Dobrikov, Georgi; Dimitrov, Vladimir; Denic, Marija S.; Radulovic, Niko S.; Vukicevic, Rastko D.
Helvetica Chimica Acta, 2013 , vol. 96, # 6 p. 1103 - 1110
反应条件
1: AlCl3, aluminium chloride 2: toluene-4-sulfonic acid / toluene; water / 8 h / |Dean-Stark; |Reflux View Scheme
参考文献
Stevanovic, Dragana; Pejovic, Anka; Damljanovic, Ivan S.; Vukicevic, Mirjana D.; Dobrikov, Georgi; Dimitrov, Vladimir; Denic, Marija S.; Radulovic, Niko S.; Vukicevic, Rastko D.
Helvetica Chimica Acta, 2013 , vol. 96, # 6 p. 1103 - 1110
反应条件
aluminium trichloride in dichloromethane
参考文献
Senda, Yasuhisa; Kanto, Hiroko; Itoh, Hiroki
Journal of the Chemical Society. Perkin Transactions 2, 1997 , # 6 p. 1143 - 1146
反应条件
1: With lithium hydroxide hydrate; water in tetrahydrofuran T=50°C; 1 h; 2: With hydrogenchloride in water pH=1;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; EBEL, Heiner; FRATTINI, Sara; GIOVANNINI, Riccardo; HOENKE, Christoph; SCHEUERER, Stefan
Patent: WO2011/151251 A1, 2011 ;
Location in patent: Page/Page column 73-74 ;
WO 2011/151251 A1
