2-甲基-6-氰基苯并噻唑合成路线 （共 9 条）
反应条件
1: 6-amino-2-methylbenzothiazole With sulfuric acid; sodium nitrite T=-2 - 2°C; 2: sodium cyanide With sodium hydroxide T=20°C; Sandmeyer reaction; 0.166667 h;
参考文献
Hrobarik, Peter; Sigmundova, Ivica; Zahradnik, Pavol
Synthesis, 2005 , # 4 art. no. P11804SS, p. 600 - 604
反应条件
1: 6-amino-2-methylbenzothiazole With hydrogenchloride; sodium nitrite T=0°C; 2: potassium cyanide With copper(II) sulfate T=50°C; 0.5 h;
参考文献
Caleta; Grdisa; Mrvos-Sermek; Cetina; Tralic-Kulenovic; Pavelic; Karminski-Zamola
Farmaco, 2004 , vol. 59, # 4 p. 297 - 305
反应条件
1.1: 86 percent / Fe; aq. HCl / ethanol / 0.33 h / 90 °C / sonification 2.1: aq. H2SO4; NaNO2 / -2 - 2 °C 2.2: 57 percent / CuCN; aq. NaOH / 0.17 h / 20 °C View Scheme
参考文献
Caleta; Grdisa; Mrvos-Sermek; Cetina; Tralic-Kulenovic; Pavelic; Karminski-Zamola
Farmaco, 2004 , vol. 59, # 4 p. 297 - 305
反应条件
1.1: 58 percent / H2SO4; HNO3 / 20 °C 2.1: 76 percent / SnCl2*2H2O; aq. HCl / methanol / 0.5 h / Heating 3.1: NaNO2; aq. HCl / 0 °C 3.2: 59.5 percent / aq. CuSO4 / 0.5 h / 50 °C View Scheme
参考文献
Caleta; Grdisa; Mrvos-Sermek; Cetina; Tralic-Kulenovic; Pavelic; Karminski-Zamola
Farmaco, 2004 , vol. 59, # 4 p. 297 - 305
反应条件
sodium hydroxide; potassium hexacyanoferrate(III)
参考文献
Mizuno; Adachi
Yakugaku Zasshi, 1952 , vol. 72, p. 739,742
反应条件
1: xylene; K2S; P2S5 2: K3<Fe(CN)6>; aqueous NaOH View Scheme
参考文献
Mizuno; Adachi
Yakugaku Zasshi, 1952 , vol. 72, p. 739,742
参考文献
Kiprianow; Uschenko
Zhurnal Obshchei Khimii, 1945 , vol. 15, p. 207,208, 212, 213
Chem.Abstr., 1946 , p. 2309
反应条件
1: aq.-ethanolic NaOH View Scheme
参考文献
Saikachi; Yoshina
Yakugaku Zasshi, 1958 , vol. 78, p. 376,379
Chem.Abstr., 1958 , p. 14587
反应条件
1: aq.-ethanolic NaOH
3: N2H4+H2O
View Scheme
参考文献
Saikachi; Yoshina
Yakugaku Zasshi, 1958 , vol. 78, p. 376,379
Chem.Abstr., 1958 , p. 14587
