5-羟基-2-硝基苯甲醛合成路线 （共 59 条）
参考文献
Mason
Journal of the Chemical Society, 1925 , vol. 127, p. 1199
反应条件
1: 98 percent / K2CO3 / dimethylformamide 2: 75 percent / aq. KOH 3: oxalyl chloride / benzene; dimethylformamide / 0.5 h 4: aq. Na2CO3 / tetrahydrofuran / 1 h / Ambient temperature View Scheme
参考文献
Venuti, Michael C.; Jones, Gordon H.; Alvarez, Robert; Bruno, John J.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 303 - 318
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
Venuti, Michael C.; Jones, Gordon H.; Alvarez, Robert; Bruno, John J.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 303 - 318
反应条件
1: 96 percent / Cs2CO3 / dimethylformamide / 15 h / 20 °C 2: 88 percent / NH2OH*HCl; MgSO4; p-TsOH*H2O / toluene / 15 h / Heating View Scheme
参考文献
Manetsch, Roman; Zheng, Lei; Reymond, Martine T.; Woggon, Wolf-Dietrich; Reymond, Jean-Louis
Chemistry - A European Journal, 2004 , vol. 10, # 10 p. 2487 - 2506
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C 2: hydrogenchloride; iron / ethanol; water / 2 h / 95 °C View Scheme
参考文献
Ren, Lei; Lei, Tao; Ye, Jia-Xi; Gong, Liu-Zhu
Angewandte Chemie - International Edition, 2012 , vol. 51, # 3 p. 771 - 774
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2: toluene-4-sulfonic acid / toluene / 100 °C 3: platinum(IV) oxide; hydrogen; sodium acetate / ethyl acetate / 20 °C 4: triethylamine / tetrahydrofuran / 0.5 h / 0 °C 5: hydrogenchloride; water / acetone / 2 h / 20 °C 6: ammonia / 5 h / 130 °C / Cooling with acetone-dry ice 7: trichlorophosphate / 4 h / 95 - 100 °C / Reflux View Scheme
参考文献
Ramurthy, Savithri; Costales, Abran; Jansen, Johanna M.; Levine, Barry; Renhowe, Paul A.; Shafer, Cynthia M.; Subramanian, Sharadha
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1678 - 1681
反应条件
1: diluted alkaline solution / 60 °C 2: permanganate View Scheme
参考文献
Heilbron et al.
Journal of the Chemical Society, 1925 , vol. 127, p. 2171
反应条件
sodium hydroxide; dihydrogen peroxide in water 16 h; Heating;
参考文献
Madani, Hadi; Thompson, Andrew S; Threadgill, Michael D
Tetrahedron, 2002 , vol. 58, # 40 p. 8107 - 8111
反应条件
1.1: 94 percent / Cs2CO3 / dimethylformamide / 72 h / 20 °C 2.1: 71 percent / piperidine; pyridine / 4 h / Heating 3.1: H2; AcOH / 10 percent Pd-C / 14 h / 20 °C 3.2: 88 percent / AcOH / 1 h / 70 °C View Scheme
参考文献
Iyobe; Uchida; Kamata; Hotel; Kusama; Harada
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 7 p. 822 - 829
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile T=20°C;
参考文献
Wadsworth, Alan H.; Lawrie, Kenneth W. M.
Journal of Labelled Compounds and Radiopharmaceuticals, 2007 , vol. 50, # 5-6 p. 526 - 527
