5,6,7,8-四氢-1-萘甲酸合成路线 （共 37 条）
反应条件
2: palladium/charcoal View Scheme
参考文献
Newman; Bye
Journal of the American Chemical Society, 1952 , vol. 74, p. 905,907
反应条件
1.1: SOCl2; DMF / toluene / 1.42 h / 20 - 50 °C 2.1: 13.14 g / toluene / 0 °C 3.1: BuLi / tetrahydrofuran; hexane / 0.67 h / -70 - -65 °C 3.2: 92 percent / tetrahydrofuran; hexane / -70 - 20 °C 4.1: 77 percent / aq. HCl / 0.75 h 5.1: 63 percent / 45 h / 110 - 115 °C View Scheme
参考文献
Clark; Miller; Berger; Repke; Weinhardt; Kowalczyk; Eglen; Bonhaus; Lee; Michel; Smith; Wong
Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2645 - 2657
反应条件
1.1: SOCl2; DMF / toluene / 1.42 h / 20 - 50 °C 2.1: 13.14 g / toluene / 0 °C 3.1: BuLi / tetrahydrofuran; hexane / 0.67 h / -70 - -65 °C 3.2: 92 percent / tetrahydrofuran; hexane / -70 - 20 °C 4.1: 77 percent / aq. HCl / 0.75 h View Scheme
参考文献
Kowalczyk, Bruce A.
Synthesis, 2000 , # 8 p. 1113 - 1116
参考文献
Fenton et al.
Journal of the American Chemical Society, 1955 , vol. 77, p. 979,980
参考文献
Sergiewskaja; Nichamkina
Zhurnal Obshchei Khimii, 1945 , vol. 15, p. 940,943
Chem.Abstr., 1946 , p. 6453
反应条件
potassium hydrogensulfate; LiAlH4 in tetrahydrofuran; diethyl ether
参考文献
Warner-Lambert Company
Patent: US5610177 A1, 1997 ;
US 5610177 A
反应条件
1: 87 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating
2: 78 percent / MnO2 / CH2Cl2 / 10 h / Heating
View Scheme
参考文献
Connolly, Terrence J.; Durst, Tony
Tetrahedron, 1997 , vol. 53, # 47 p. 15969 - 15982
