4-乙酰氨基-5-氯-2-乙氧基苯甲酸甲酯合成路线 （共 9 条）
反应条件
N-chloro-succinimide in N,N-dimethyl-formamide T=70°C; 2 h;
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 2 p. 616 - 624
反应条件
1: 98.4 percent / K2CO3 / dimethylformamide / 24 h / 20 - 30 °C 2: NCS / dimethylformamide / 3 h / 70 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 46, # 1 p. 42 - 52
反应条件
1: sulfuric acid / 2 h / 20 °C 2: acetic acid / 1 h 3: sodium hydroxide / N,N-dimethyl-formamide 4: N-chloro-succinimide / N,N-dimethyl-formamide View Scheme
参考文献
Letters in Drug Design and Discovery, , vol. 9, # 5 p. 489 - 493
反应条件
1: acetic acid / 1 h 2: sodium hydroxide / N,N-dimethyl-formamide 3: N-chloro-succinimide / N,N-dimethyl-formamide View Scheme
参考文献
Letters in Drug Design and Discovery, , vol. 9, # 5 p. 489 - 493
反应条件
sodium hydroxide; water in ethanol 5 h; Heating;
参考文献
Kato; Morie; Kon; Yoshida; Karasawa; Matsumoto
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 616 - 624
反应条件
1: 99 percent / NaOH, H2O / ethanol / 5 h / Heating 2: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH2Cl2 / 4 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 2 p. 616 - 624
反应条件
1: 99 percent / NaOH, H2O / ethanol / 5 h / Heating 2: 1-ethyl-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH2Cl2 / 4 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 2 p. 616 - 624
反应条件
1: 99 percent / NaOH, H2O / ethanol / 5 h / Heating 2: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH2Cl2 / 4 h / Ambient temperature View Scheme
参考文献
Kato; Morie; Kon; Yoshida; Karasawa; Matsumoto
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 616 - 624
反应条件
1: 99 percent / NaOH, H2O / ethanol / 5 h / Heating 2: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH2Cl2 / 4 h / Ambient temperature View Scheme
参考文献
Kato; Morie; Kon; Yoshida; Karasawa; Matsumoto
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 616 - 624
