2-甲氧基-5-碘苯甲醛合成路线 （共 10 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C;
参考文献
Tchilibon, Susanna; Joshi, Bhalchandra V.; Kim, Soo-Kyung; Duong, Heng T.; Gao, Zhan-Guo; Jacobson, Kenneth A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 6 p. 1745 - 1758
反应条件
potassium carbonate in acetone T=20°C; 2 h;
参考文献
Toumi, Mathieu; Couty, Francois; Evano, Gwilherm
Angewandte Chemie - International Edition, 2007 , vol. 46, # 4 p. 572 - 575
反应条件
iodine; acetic acid; periodic acid; sulfuric acid in water Heating;
参考文献
Hathaway, Bruce A.; White, Kristen L.; McGill, Mark E.
Synthetic Communications, 2007 , vol. 37, # 21 p. 3855 - 3860
反应条件
1: para-iodoanisole With titanium tetrachloride in dichloromethane T=0°C; 0.5 h; 2: dichloromethoxy methane in dichloromethane T=0°C; 2 h;
参考文献
Pfizer Inc.
Patent: US6369074 B1, 2002 ;
Location in patent: Page column 27 ;
US 6369074 B1
反应条件
periodic acid in methanol T=60 - 70°C; 12 h;
参考文献
Bhatt, M. V.; Hosur, B. M.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 1004 - 1005
反应条件
1: salicylaldehyde With iodine cloride; acetic acid Inert atmosphere; 2: dimethyl sulfate With potassium carbonate in acetone Inert atmosphere;
参考文献
Toumi, Mathieu; Rincheval, Vincent; Young, Ashley; Gergeres, Danielle; Turos, Edward; Couty, Francois; Mignotte, Bernard; Evano, Gwilherm
European Journal of Organic Chemistry, 2009 , # 20 p. 3368 - 3386
反应条件
sulfuric acid; iodine; periodic acid in acetic acid T=80 - 85°C; 12 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Panetta, Charles A.; Fang, Zheng; Mattern, Daniell L.
Journal of Organic Chemistry, 1995 , vol. 60, # 24 p. 7953 - 7958
反应条件
1: 93 percent / iodine monochloride; acetic acid / 72 h / 20 - 40 °C 2: 100 percent / potassium carbonate / acetone / 2 h / 20 °C View Scheme
参考文献
Toumi, Mathieu; Couty, Francois; Evano, Gwilherm
Angewandte Chemie - International Edition, 2007 , vol. 46, # 4 p. 572 - 575
参考文献
Piel, M.; Stark, D.; Rao, M. L.; Frahnert, C.; Schirrmacher, R.; Roesch, F.
Journal of Labelled Compounds and Radiopharmaceuticals, 2003 , vol. 46, p. S161 - S161
反应条件
ammonium acetate; sodium cyanoborohydride in methanol
T=20°C; 48 h;
参考文献
GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Patent: WO2006/31505 A1, 2006 ;
Location in patent: Page/Page column 28 ;
WO 2006/031505 A1
