1: Ti(O-i-Pr)4; D(-)-DIPT; t-BuOOH / CH2Cl2 / -20 °C 2: Ti(O-i-Pr)2(N3)2 / benzene / Heating 3: H2 / Pd/C / ethyl acetate / 20 °C View Scheme

1: N-bromosuccinimide; dimethylsulphide / CH2Cl2 / 3 h / -30 - 20 °C 2: 52 percent / m-chloroperbenzoic acid / CH2Cl2 / 20 °C 3: 20 percent / n-Bu3SnH; (MeO)3P; AIBN / benzene / Heating View Scheme

1: Ti(O-i-Pr)4; D(-)-DIPT; t-BuOOH / CH2Cl2 / -20 °C 2: Ti(O-i-Pr)2(N3)2 / benzene / Heating 3: H2 / Pd/C / ethyl acetate / 20 °C 4: Ph3P; diisopropyl azodicarboxylate / CHCl3 / Heating View Scheme

1: Ti(O-i-Pr)4; D(-)-DIPT; t-BuOOH / CH2Cl2 / -20 °C 2: Ti(O-i-Pr)2(N3)2 / benzene / Heating 3: H2 / Pd/C / ethyl acetate / 20 °C 4: Ph3P; diisopropyl azodicarboxylate / CHCl3 / Heating View Scheme

1: periodic acid; RuCl3 2: NaN3 / Cu(NO3)2 / H2O / 1.5 h / 65 °C 3: NaBH4 / Cu(NO3)2 / H2O / 0.5 h / 0 °C View Scheme

1: 10.3 g / 4A molecular sieves, titanium tetraisopropoxide, diethyl D-tartrate, tert-butyl hydroperoxide / CH2Cl2; 2,2,4-trimethyl-pentane / 20 h / -22 °C 2: 2.7 g / titanium tetraisopropoxide, azidotrimethylsilane / benzene / 0.25 h / Heating 3: 1.) 2-acetoxyisobutyryl chloride, 2.) NaOMe / 1.) chloroform, RT, 5 h, 2.) THF, RT, 3 h 4: 9.63 g / propan-2-ol / 80 °C 5: 4.68 g / H2 / 10percent Pd/C / tetrahydrofuran; methanol; acetic acid / 12 h View Scheme

oxygen in dimethyl sulfoxide T=190°C;

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 8 h / 0 °C 2.1: titanium(IV) isopropylate; trimethylsilylazide / benzene / 0.25 h / 70 °C / Inert atmosphere 3.1: 4-(N,N-dimethlyamino)pyridine; di(n-butyl)tin oxide; triethylamine / dichloromethane / 3 h / 0 - 20 °C 4.1: potassium carbonate / methanol / 1 h / 0 - 25 °C 5.1: (S,S)-(salen)Co(OAc) complex; water / tetrahydrofuran / 14 h / 0 - 25 °C 6.1: isopropyl alcohol / 5 h / 50 °C 7.1: triethylamine / dichloromethane / 12.5 h / 0 - 20 °C 8.1: triphenylphosphine / tetrahydrofuran / 0.5 h / 25 °C 8.2: 29 h 9.1: triethylamine / dichloromethane / 2 h / 25 °C View Scheme

1.1: 81 percent / PCC / CH2Cl2 / 2.5 h / 20 °C 2.1: PPh3 / CH2Cl2 / 0.05 h / 0 °C 2.2: 84 percent / CH2Cl2 / 3 h / 0 °C View Scheme

1: With toluene-4-sulfonic acid; RhH(CO)(triphenylphosphine)3 72 h; Heating / reflux; 2: With sodium hydroxide T=250°C;