2-氨基-6-甲基-5-硝基-3H-嘧啶-4-酮合成路线 （共 10 条）
反应条件
sulfuric acid; nitric acid 0.75 h; Ambient temperature;
参考文献
Bowden, Keith; Bright, Andrew C.
Journal of Chemical Research, Miniprint, 1992 , # 2 p. 514 - 539
反应条件
ammonia in chloroform Heating;
参考文献
Chen; Adrian; Cushing; DiMaio; Liang; Mayorga; Miao; Peterson; Powers; Spector; Stein; Wright; Xu; Ye; Jaen
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 8 p. 2188 - 2192
反应条件
1: 79 percent / NaOAc; AcOH / ethanol; H2O 2: NH3 / CHCl3 / Heating View Scheme
参考文献
Chen; Adrian; Cushing; DiMaio; Liang; Mayorga; Miao; Peterson; Powers; Spector; Stein; Wright; Xu; Ye; Jaen
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 8 p. 2188 - 2192
反应条件
1: 87 percent / Et4NCl; N,N-dimethylaniline; POCl3 / acetonitrile / Heating 2: 79 percent / NaOAc; AcOH / ethanol; H2O 3: NH3 / CHCl3 / Heating View Scheme
参考文献
Chen; Adrian; Cushing; DiMaio; Liang; Mayorga; Miao; Peterson; Powers; Spector; Stein; Wright; Xu; Ye; Jaen
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 8 p. 2188 - 2192
反应条件
1: 91 percent / CH2Cl2 / 5 h / Ambient temperature 2: 60 percent / NaH / dimethylformamide / 1.) r.t., 1 h, 2.) r.t., 12 h 3: 86 percent / dimethylformamide / 12 h / Ambient temperature 4: 94 percent / aq. Na2S2O4 / tetrahydrofuran / 1 h / Ambient temperature View Scheme
参考文献
Taylor; Young; Ward
Tetrahedron Letters, 1993 , vol. 34, # 29 p. 4595 - 4598
反应条件
1: 27 percent / POCl3 / 3 h / Heating 2: 68 percent / NH3 / ethanol / 4 h / 100 °C View Scheme
参考文献
Bowden, Keith; Bright, Andrew C.
Journal of Chemical Research, Miniprint, 1992 , # 2 p. 514 - 539
反应条件
1: 80 percent / dimethylformamide / 24 h / 100 °C 2: 61 percent / sodium dithionite / H2O / 2 h / Heating View Scheme
参考文献
Taylor; Young; Ward
Tetrahedron Letters, 1993 , vol. 34, # 29 p. 4595 - 4598
反应条件
1.1: Heating 2.1: POCl3; N,N-diethylaniline / 0.08 h / Heating 2.2: 11.0 g / phenylmethanol / 1 h View Scheme
参考文献
Evans; Furneaux; Hutchison; Kezar; Morris, Jr.; Schramm; Tyler
Journal of Organic Chemistry, 2001 , vol. 66, # 17 p. 5723 - 5730
反应条件
in dichloromethane T=20°C; Condensation; 1 h;
参考文献
Gibson, Eric S.; Lesiak, Krystyna; Watanabe, Kyoichi A.; Gudas, Lorraine J.; Pankiewicz, Krzysztof W.
Nucleosides and Nucleotides, 1999 , vol. 18, # 3 p. 363 - 376
反应条件
1: 27 percent / POCl3 / 3 h / Heating
2: 68 percent / NH3 / ethanol / 4 h / 100 °C
3: 34 percent / iron(II) sulphate, H2O, Ba(OH)2 / 0.33 h / 100 °C
View Scheme
参考文献
Bowden, Keith; Bright, Andrew C.
Journal of Chemical Research, Miniprint, 1992 , # 2 p. 514 - 539
