5-氯-2,2-二甲基戊腈合成路线 （共 13 条）
反应条件
1: NaI / acetone / Heating 2: Mg, BrCH2CH2Br / diethyl ether View Scheme
参考文献
Caille, Seb; Crockett, Rich; Ranganathan, Krishnakumar; Wang, Xiang; Woo, Jacqueline C. S.; Walker, Shawn D.
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5198 - 5206
反应条件
tetra(n-butyl)ammonium hydrogensulfate in water T=100°C; 2 h;
参考文献
BASF Aktiengesellschaft
Patent: US6344580 B1, 2002 ;
Location in patent: Example 2 ;
反应条件
tetra(n-butyl)ammonium hydrogen sulphate in water
参考文献
Wong, George S. K.
Patent: US2002/13489 A1, 2002 ;
反应条件
in N,N-dimethyl-formamide T=100°C; 3 h;
参考文献
Davis, Matthew C.; Baldwin, Lawrence C.
Synthetic Communications, 2010 , vol. 40, # 10 p. 1437 - 1444
参考文献
Truce,W.E. et al.
Journal of Organic Chemistry, 1962 , vol. 27, p. 2821 - 2828
反应条件
lithium hexamethyldisilazane
T=70°C; 16 h;
参考文献
ARRAY BIOPHARMA INC.; ALLEN, Shelley; BRANDHUBER, Barbara J.; CONDROSKI, Kevin Ronald; HUANG, Lily; KERCHER, Timothy; WINSKI, Shannon L.
Patent: WO2014/78408 A1, 2014 ;
Location in patent: Paragraph 00488 ;
参考文献
Wong, George S. K.
Patent: US2002/13489 A1, 2002 ;
反应条件
1: iso-butyronitrile With lithium diisopropyl amide in tetrahydrofuran; hexane
T=-78°C; 0.666667 h; Inert atmosphere;
2: 1-bromo-3-chloro-propane in tetrahydrofuran; hexane
T=20°C; Inert atmosphereCooling with ice; regioselective reaction;
参考文献
Davis, Matthew C.; Baldwin, Lawrence C.
Synthetic Communications, 2010 , vol. 40, # 10 p. 1437 - 1444
反应条件
tin(IV) chloride in dichloromethane
20 h; Ambient temperature;
参考文献
Reetz, Manfred T.; Chatziiosifidis, Ioannis
Angewandte Chemie, 1981 , vol. 93, # 12 p. 1075 - 1076
参考文献
Truce,W.E. et al.
Journal of Organic Chemistry, 1962 , vol. 27, p. 2821 - 2828
