3,5-二甲基-4-羟基苯甲腈合成路线 （共 25 条）
反应条件
palladium (II) trifluoroacetate; C21H34NPSi; sodium carbonate in N,N-dimethyl acetamide T=140°C; 16 h; Inert atmosphere;
参考文献
Schareina, Thomas; Jackstell, Ralf; Schulz, Thomas; Zapf, Alexander; Cotte, Alain; Gotta, Matthias; Beller, Matthias
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 4 p. 643 - 648
反应条件
CuCN in hexane; dichloromethane; N,N-dimethyl-formamide
参考文献
Sterling Winthrop Inc.
Patent: US5464848 A1, 1995 ;
US 5464848 A
反应条件
in water; N,N-dimethyl-formamide
参考文献
Aspnes, Gary E.; Chiang, Yuan-Ching P.
Patent: US2002/6946 A1, 2002 ;
US 20020006946 A1
反应条件
1: With sulfuric acid in water T=5°C; 2: With water; sodium nitrite T=80°C; 1.5 h; Cooling;
参考文献
Hou, Shili; Li, Xinyao; Xu, Jiaxi
Journal of Organic Chemistry, 2012 , vol. 77, # 23 p. 10856 - 10869
反应条件
Cu(NO3)2*3H2O; cesium fluoride in methanol; water T=100°C; 4 h;
参考文献
Liskey, Carl W.; Liao, Xuebin; Hartwig, John F.
Journal of the American Chemical Society, 2010 , vol. 132, # 33 p. 11389 - 11391
反应条件
1.1: copper(l) iodide; potassium iodide; N-methyl-2-(methylamino)ethylamine / N,N-dimethyl-formamide / 24 h / 100 °C / |Inert atmosphere 2.1: sulfuric acid / water / 5 °C 2.2: 1.5 h / 80 °C / |Cooling View Scheme
参考文献
Hou, Shili; Li, Xinyao; Xu, Jiaxi
Journal of Organic Chemistry, 2012 , vol. 77, # 23 p. 10856 - 10869
反应条件
1.1: sulfuric acid; boric acid; dihydrogen peroxide; potassium bromide / water / 3 h / 20 °C 2.1: copper(l) iodide; potassium iodide; N-methyl-2-(methylamino)ethylamine / N,N-dimethyl-formamide / 24 h / 100 °C / |Inert atmosphere 3.1: sulfuric acid / water / 5 °C 3.2: 1.5 h / 80 °C / |Cooling View Scheme
参考文献
Hou, Shili; Li, Xinyao; Xu, Jiaxi
Journal of Organic Chemistry, 2012 , vol. 77, # 23 p. 10856 - 10869
反应条件
potassium cyanide; samarium diiodide; 18-crown-6 ether 1.) CH2Cl2, room t., 20 min, 2.) THF, MeOH, -78 deg C; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Olson, Steven H.; Danishefsky, Samuel J.
Tetrahedron Letters, 1994 , vol. 35, # 43 p. 7901 - 7904
反应条件
in N,N-dimethyl-formamide
参考文献
Fujio,M. et al.
Bulletin of the Chemical Society of Japan, 1975 , vol. 48, p. 2127 - 2133
反应条件
pyridine; copper(II) sulfate
参考文献
Bielig; Luetzel
Justus Liebigs Annalen der Chemie, 1957 , vol. 608, p. 140,156
