1-乙酰-1,2,3,4-四氢喹啉合成路线 （共 29 条）
反应条件
in dichloromethane T=0 - 25°C;
参考文献
Gruenenthal GmbH
Patent: US2010/234340 A1, 2010 ;
Location in patent: Page/Page column 22 ;
US 20100234340 A1
反应条件
acetic anhydride in 1,2-dichloro-ethane T=20°C; 4 h;
参考文献
Katayama, Hajime; Tachikawa, Yoshio; Takatsu, Noriyuki; Kato, Akira
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 7 p. 2220 - 2233
反应条件
pyridine in dichloromethane T=0 - 25°C; 1 h;
参考文献
Cordeiro, Alessandra; Shaw, Julian; O'Brien, John; Blanco, Fernando; Rozas, Isabel
European Journal of Organic Chemistry, 2011 , # 8 p. 1504 - 1513
反应条件
tris-(dibenzylideneacetone)dipalladium(0); trifuran-2-yl-phosphane; caesium carbonate in toluene T=110°C; 21 h;
参考文献
Wolfe, John P.; Rennels, Roger A.; Buchwald, Stephen L.
Tetrahedron, 1996 , vol. 52, # 21 p. 7525 - 7546
反应条件
ozonized air in methanol T=-40°C;
参考文献
Katayama, Hajime; Tachikawa, Yoshio; Takatsu, Noriyuki; Kato, Akira
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 7 p. 2220 - 2233
反应条件
diethyl-1,4-dihydro-2,6-dimethyl-3,5-pyridine dicarboxylate in dichloromethane T=20°C; 0.5 h;
参考文献
Babu, Thelagathoti Hari; Shanthi, Gnanamani; Perumal, Paramasivan T.
Tetrahedron Letters, 2009 , vol. 50, # 24 p. 2881 - 2884
反应条件
sodium tetrahydroborate
参考文献
Katayama, Hajime; Ohkoshi, Mitsuko; Yasue, Masaiti
Chemical & Pharmaceutical Bulletin, 1980 , vol. 28, # 7 p. 2226 - 2228
反应条件
1: 99 percent / sodium bicarbonate, tetra-n-butyl ammonium chloride, palladium acetate / dimethylformamide / 48 h / 40 °C 2: 88 percent / NaBH4 / 1,2-dimethoxy-ethane; methanol / 15 h / 70 °C 3: 84 percent / AlCl3, LiAlH4 / diethyl ether / 18 h 4: 49 percent / Et3N / CH2Cl2 / 2 h 5: 43 percent / Cs2CO3, tris(dibenzylideneacetone)dipalladium(0), tri-(2-furyl)phosphine / toluene / 21 h / 110 °C View Scheme
参考文献
Wolfe, John P.; Rennels, Roger A.; Buchwald, Stephen L.
Tetrahedron, 1996 , vol. 52, # 21 p. 7525 - 7546
反应条件
1: 88 percent / NaBH4 / 1,2-dimethoxy-ethane; methanol / 15 h / 70 °C 2: 84 percent / AlCl3, LiAlH4 / diethyl ether / 18 h 3: 49 percent / Et3N / CH2Cl2 / 2 h 4: 43 percent / Cs2CO3, tris(dibenzylideneacetone)dipalladium(0), tri-(2-furyl)phosphine / toluene / 21 h / 110 °C View Scheme
参考文献
Wolfe, John P.; Rennels, Roger A.; Buchwald, Stephen L.
Tetrahedron, 1996 , vol. 52, # 21 p. 7525 - 7546
反应条件
1: 49 percent / Et3N / CH2Cl2 / 2 h 2: 43 percent / Cs2CO3, tris(dibenzylideneacetone)dipalladium(0), tri-(2-furyl)phosphine / toluene / 21 h / 110 °C View Scheme
参考文献
Wolfe, John P.; Rennels, Roger A.; Buchwald, Stephen L.
Tetrahedron, 1996 , vol. 52, # 21 p. 7525 - 7546
