5,6-二氯烟酸合成路线

参考文献

XENON PHARMACEUTICALS INC.; GENENTECH, INC; Chowdhury, Sultan; Dehnhardt, Christoph Martin; Focken, Thilo; Grimwood, Michael Edward; Hemeon, Ivan William; Jia, Qi; Ortwine, Daniel; Safina, Brian; Sun, Shaoyi; Sutherlin, Daniel P.; Zenova, Alla Yurevna
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65189-15-35,6-二氯烟腈

41667-95-25,6-二氯烟酸

参考文献

Raeth; Schiffmann
Justus Liebigs Annalen der Chemie, 1931 , vol. 487, p. 127,129

54127-63-85-氯-6-羟基烟酸+

10026-13-8五氯化磷+

10025-87-3三氯氧磷

41667-95-25,6-二氯烟酸

参考文献

v. Pechmann; Mills
Chemische Berichte, 1904 , vol. 37, p. 3830

67-56-1甲醇+

41667-95-25,6-二氯烟酸

56055-54-05,6-二氯烟酸甲酯

参考文献

DAEWOONG PHARMACEUTICAL CO., LTD.
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41667-95-25,6-二氯烟酸+

18107-18-1三甲基硅烷化重氮甲烷

56055-54-05,6-二氯烟酸甲酯

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41667-95-25,6-二氯烟酸

56055-54-05,6-二氯烟酸甲酯

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Wang, Wei-Bo; Curtin, Michael L.; Fakhoury, Stephen A.; Gwaltney II, Stephen L.; Hasvold, Lisa A.; Hutchins, Charles W.; Li, Qun; Lin, Nan-Horng; Nelson, Lissa Taka Jennings; O'Connor, Steve; Sham, Hing L.; Sullivan, Gerard M.; Wang, Gary T.; Wang, Xilu
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64-17-5乙醇+

41667-95-25,6-二氯烟酸

401566-69-63-氨基-4-羟基吡啶盐酸盐

参考文献

WO2008/29370 A1, ;

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41667-95-25,6-二氯烟酸+

144-55-8碳酸氢钠

401566-69-63-氨基-4-羟基吡啶盐酸盐

参考文献

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41667-95-25,6-二氯烟酸

220656-93-95-氯-6-甲氧基烟酸甲酯

参考文献

Bolli, Martin; Lescop, Cyrille; Mathys, Boris; Mueller, Claus; Nayler, Oliver; Steiner, Beat; Velker, Jorg
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67-56-1甲醇+

41667-95-25,6-二氯烟酸

884494-85-35-氯-6-甲氧基烟酸

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WO 2009/024905 A1