N-甲基-4-硝基邻苯二甲酰亚胺合成路线 （共 18 条）
反应条件
potassium fluoride on basic alumina in 2-methyl tetrahydrofuran 5 h; Inert atmosphereReflux; chemoselective reaction;
参考文献
Pace, Vittorio; Hoyos, Pilar; Fernandez, Maria; Sinisterra, Jose V.; Alcantara, Andres R.
Green Chemistry, 2010 , vol. 12, # 8 p. 1380 - 1382
反应条件
acetic anhydride; methylamine in ethanol
参考文献
University of Kentucky Research Foundation
Patent: US7759468 B1, 2010 ;
反应条件
sulfuric acid; nitric acid T=65°C;
参考文献
Duan, Xin-Hong; Qiao, Jin-Ping; Yang, Yang; Cui, Meng-Chao; Zhou, Jiang-Ning; Liu, Bo-Li
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 3 p. 1337 - 1343
反应条件
N,N,N',N,-tetramethylethylenediamine in N,N-dimethyl-formamide T=95°C; 12 h;
参考文献
Zhao, Sheng-Yin; Zhang, Hai-Quan; Zhang, Deng-Qing; Shao, Zhi-Yu
Synthetic Communications, 2012 , vol. 42, # 1 p. 128 - 135
反应条件
N,N-dimethyl-formamide T=135 - 145°C;
参考文献
Billman; Cash
Journal of the American Chemical Society, 1953 , vol. 75, p. 2499,2500
反应条件
nitric acid; anhydrous sulphate; zirconium oxide in tetrachloromethane T=20°C; 17 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Nagi, Sh. M.; Zubkov, E. A.; Shubin, V. G.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1990 , vol. 39, # 7.2 p. 1500 - 1502
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1990 , # 7 p. 1650 - 1652
反应条件
1: in ethanol T=0°C; 2 h; 2: With acetic anhydride 0.25 h; Reflux;
参考文献
Neelakantan, Sundar; Surjawan, Iwan; Karacelik, Huseyin; Hicks, Clair L.; Crooks, Peter A.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 19 p. 5722 - 5726
反应条件
1: 5-nitro-isoindole-1,3-dione With potassium hydroxide in methanol; ethanol T=20°C; 3 h; 2: halomethane With potassium carbonate in N,N-dimethyl-formamide 1 h; Reflux;
参考文献
Bian, Xiaoli; Wang, Qian; Ke, Changhu; Zhao, Guilan; Li, Yiping
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 7 p. 2022 - 2026
反应条件
in dimethyl sulfoxide T=142°C; 3.5 h;
参考文献
Relles, Howard M.; Johnson, Donald S.; Dellacoletta, B. A.
Journal of Organic Chemistry, 1980 , vol. 45, # 8 p. 1374 - 1379
反应条件
1.1: nitric acid; sulfuric acid / 16 h / 5 - 20 °C 2.1: potassium hydroxide / methanol; ethanol / 3 h / 20 °C 2.2: 1 h / |Reflux View Scheme
参考文献
Bian, Xiaoli; Wang, Qian; Ke, Changhu; Zhao, Guilan; Li, Yiping
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 7 p. 2022 - 2026
