4,8-二氧杂十一烷-1,11-二醇合成路线 （共 11 条）
反应条件
1: With lithium aluminium tetrahydride
2: With water
参考文献
UNIVERSITY OF TOLEDO
Patent: WO2009/152392 A2, 2009 ;
Location in patent: Page/Page column 25 ;
WO 2009/152392 A2
反应条件
Me2S*BH2Cl in diethyl ether
12 h; Ambient temperature;
参考文献
Martinez-Bernhardt, Rolando; Castro, Peter P.; Godjoian, Gayane; Gutierrez, Carlos G.
Tetrahedron, 1998 , vol. 54, # 31 p. 8919 - 8932
反应条件
palladium 10 on activated carbon; hydrogen in methanol
T=20°C; 30 h;
参考文献
LaFrate, Andrew L.; Carlson, Kathryn E.; Katzenellenbogen, John A.
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 10 p. 3528 - 3535
反应条件
1: With trifluorormethanesulfonic acid
T=180°C; Inert atmosphere;
2: With XUS ion exchange resin
T=105°C; Inert atmosphere;
参考文献
E. I. DU PONT DE NEMOURS AND COMPANY
Patent: US2011/224307 A1, 2011 ;
Location in patent: Page/Page column 7 ;
反应条件
hydrogenchloride in methanol; dichloromethane
24 h; Ambient temperature;
参考文献
Czech, Bronislaw P.; Babb, David A.; Son, Byungki; Bartsch, Richard A.
Journal of Organic Chemistry, 1984 , vol. 49, # 25 p. 4805 - 4810
反应条件
potassium hydroxide
1.) THF; Yield given. Multistep reaction;
参考文献
Liu, Yu; Inoue, Yoshihisa; Hakushi, Tadao
Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 10 p. 3044 - 3046
反应条件
1: 92 percent / p-TsOH / toluene / Heating
2: 92 percent / BH3*THF / tetrahydrofuran / 96 h / Heating
View Scheme
参考文献
Martinez-Bernhardt, Rolando; Castro, Peter P.; Godjoian, Gayane; Gutierrez, Carlos G.
Tetrahedron, 1998 , vol. 54, # 31 p. 8919 - 8932
参考文献
Kitazawa, Sadaya; Kimura, Keiichi; Yano, Hideki; Shono, Toshiyuki
Journal of the American Chemical Society, 1984 , vol. 106, # 23 p. 6978 - 6983
反应条件
USY H+ zeolite
T=150°C; 24 h; Conversion of starting material;
参考文献
Brewer, Stephen Edward; Diaz, Zaida; Powell, Joseph Broun; Weider, Paul Richard; Komplin, Glenn Charles; Blackbourn, Robert Lawrence
Patent: US2004/87818 A1, 2004 ;
Location in patent: Page 4 ;
反应条件
Amberlyst A15 resin
T=100°C; 1 - 5 h; Conversion of starting material;
参考文献
Powell, Joseph Broun; Weider, Paul Richard; Komplin, Glenn Charles
Patent: US2004/87819 A1, 2004 ;
Location in patent: Page 3-4 ;
