N-苄氧羰基-L-谷氨酸酐合成路线 （共 62 条）
反应条件
1: Heating 3: (i) aq. NaOH, dioxane, (ii) H2, MeOH, Pd-C View Scheme
参考文献
Lieflaender,M.
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1960 , vol. 320, p. 35 - 57
参考文献
Kasai, Takanori; Hirakuri, Yoshihiro; Sakamura, Sadao
Agricultural and Biological Chemistry, 1981 , vol. 45, # 2 p. 433 - 438
反应条件
anschliessendes Hydrieren;
参考文献
Matsukawa; Masuda
Yakugaku Zasshi, 1953 , vol. 73, p. 397
Chem.Abstr., 1954 , p. 2597
反应条件
1: ethyl acetate 2: aq. NaOH solution 3: palladium; aqueous acetic acid; methanol / Hydrogenation View Scheme
参考文献
Bergmann et al.
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1934 , vol. 224, p. 17,24
反应条件
1: dicyclohexylamine (DCHA) / tetrahydrofuran / 0 °C 2: 70percent perchloric acid / Ambient temperature 3: 100 percent / 1 M KOH / methanol 4: triethylamine / tetrahydrofuran / 1 h / 0 °C 5: sodium borohydride / tetrahydrofuran; H2O / 4 h / Ambient temperature View Scheme
参考文献
Dolence, E. Kurt; Lin, Chia-En; Miller, Marvin J.; Payne, Shelley M.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 956 - 968
反应条件
1: With 1,1-dimethylethylmagnesium chloride in tetrahydrofuran T=-78°C; 4 h; 2: With citric acid in tetrahydrofuran
参考文献
Deguest, Geoffrey; Bischoff, Laurent; Fruit, Corinne; Marsais, Francis
Tetrahedron Asymmetry, 2006 , vol. 17, # 14 p. 2120 - 2125
反应条件
1: thien-2-yl bromide With magnesium in tetrahydrofuran T=40°C; 2 h; 2: benzyl 2,6-dioxotetrahydro-2H-pyran-3-ylcarbamate in tetrahydrofuran T=-78°C; 4 h; 3: With citric acid in tetrahydrofuran T=-78 - 20°C; Title compound not separated from byproducts;
参考文献
Deguest, Geoffrey; Bischoff, Laurent; Fruit, Corinne; Marsais, Francis
Tetrahedron Asymmetry, 2006 , vol. 17, # 14 p. 2120 - 2125
反应条件
1: 1-bromo-butane With magnesium in tetrahydrofuran T=40°C; 2 h; 2: benzyl 2,6-dioxotetrahydro-2H-pyran-3-ylcarbamate in tetrahydrofuran T=-78°C; 4 h; 3: With citric acid in tetrahydrofuran T=-78 - 20°C; Title compound not separated from byproducts;
参考文献
Deguest, Geoffrey; Bischoff, Laurent; Fruit, Corinne; Marsais, Francis
Tetrahedron Asymmetry, 2006 , vol. 17, # 14 p. 2120 - 2125
反应条件
1: 3-methoxybromobenzene With magnesium in tetrahydrofuran T=40°C; 2 h; 2: benzyl 2,6-dioxotetrahydro-2H-pyran-3-ylcarbamate in tetrahydrofuran T=-78°C; 4 h; 3: With citric acid in tetrahydrofuran T=-78 - 20°C; Title compound not separated from byproducts;
参考文献
Deguest, Geoffrey; Bischoff, Laurent; Fruit, Corinne; Marsais, Francis
Tetrahedron Asymmetry, 2006 , vol. 17, # 14 p. 2120 - 2125
反应条件
1: 1-bromo-hexane With magnesium in tetrahydrofuran T=40°C; 2 h; 2: benzyl 2,6-dioxotetrahydro-2H-pyran-3-ylcarbamate in tetrahydrofuran T=-78°C; 4 h; 3: With citric acid in tetrahydrofuran T=-78 - 20°C; Title compound not separated from byproducts;
参考文献
Deguest, Geoffrey; Bischoff, Laurent; Fruit, Corinne; Marsais, Francis
Tetrahedron Asymmetry, 2006 , vol. 17, # 14 p. 2120 - 2125
