苯基-(4-苯基-2-苯基氨基-噻唑-5-基)-甲酮合成路线 （共 10 条）
反应条件
1: N,N-diethyl-benzamidine; phenyl isothiocyanate in N,N-dimethyl-formamide
T=20 - 25°C;
2: α-bromoacetophenone in N,N-dimethyl-formamide
T=20°C;
参考文献
Jalani, Hitesh B.; Pandya, Amit N.; Pandya, Dhaivat H.; Sharma, Jayesh A.; Sudarsanam; Vasu, Kamala K.
Tetrahedron Letters, 2013 , vol. 54, # 39 p. 5403 - 5406
反应条件
triethylamine in acetone
T=20°C; Condensation; Cyclization;
参考文献
Romero-Ortega, Moises; Aviles, Adriana; Cruz, Raymundo; Fuentes, Aydee; Gomez, Rosa Maria; Plata, Andres
Journal of Organic Chemistry, 2000 , vol. 65, # 21 p. 7244 - 7247
反应条件
N-bromosuccinmide; meta-chloroperoxybenzoic acid in benzene
6 h; Heating;
参考文献
Dahiya, Rajinder; Pujari, H. K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 966
反应条件
1: 76 percent / NaOH / H2O; tetrahydrofuran / 0 °C
2: 78 percent / Et3N / acetone / 20 °C
View Scheme
参考文献
Romero-Ortega, Moises; Aviles, Adriana; Cruz, Raymundo; Fuentes, Aydee; Gomez, Rosa Maria; Plata, Andres
Journal of Organic Chemistry, 2000 , vol. 65, # 21 p. 7244 - 7247
反应条件
1: 76 percent / NaOH / H2O; tetrahydrofuran / 0 °C
2: 78 percent / Et3N / acetone / 20 °C
View Scheme
参考文献
Romero-Ortega, Moises; Aviles, Adriana; Cruz, Raymundo; Fuentes, Aydee; Gomez, Rosa Maria; Plata, Andres
Journal of Organic Chemistry, 2000 , vol. 65, # 21 p. 7244 - 7247
反应条件
in acetonitrile
T=0°C; 5 h;
参考文献
Scheiff, Anja B.; Yerande, Swapnil G.; El-Tayeb, Ali; Li, Wenjin; Inamdar, Gajanan S.; Vasu, Kamala K.; Sudarsanam, Vasudevan; Mueller, Christa E.
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 6 p. 2195 - 2203
参考文献
Muraw'ewa; Schtschukina
Doklady Akademii Nauk SSSR, 1959 , vol. 126, p. 1274,1275, 1277
Doklady Chemistry, 124-129 <1959> 467, 468, 469
参考文献
Ziemelis,Z. et al.
Doklady Chemistry, 1965 , vol. 164, p. 840 - 843
Doklady Akademii Nauk SSSR, 1965 , vol. 164, p. 106 - 109
参考文献
Muraw'ewa; Schtschukina
Doklady Akademii Nauk SSSR, 1959 , vol. 126, p. 1274,1275, 1277
Doklady Chemistry, 124-129 <1959> 467, 468, 469
反应条件
(i) EtOH, (ii) /BRN= 605631/; Multistep reaction;
参考文献
Ziemelis,Z. et al.
Doklady Chemistry, 1965 , vol. 164, p. 840 - 843
Doklady Akademii Nauk SSSR, 1965 , vol. 164, p. 106 - 109
