1-(3-（甲基苯基）哌啶合成路线 （共 15 条）
反应条件
1: piperazine With [2,2']bipyridinyl; nickel diacetate; sodium hydride; 1,1-dimethylpropan-1-ol in tetrahydrofuran T=65°C; 2 h; 2: 1-chloro-3-methylbenzene With styrene in tetrahydrofuran T=65°C; 6 h;
参考文献
Brenner, Eric; Schneider, Raphael; Fort, Yves
Tetrahedron, 2002 , vol. 58, # 34 p. 6913 - 6924
反应条件
1: piperazine With [2,2']bipyridinyl; 1,1-dimethylpropan-1-ol; nickel diacetate in tetrahydrofuran T=63°C; complex formation; 2 h; 2: 1-chloro-3-methylbenzene With styrene in tetrahydrofuran Arylation; 6 h; Heating;
参考文献
Brenner, Eric; Schneider, Raphael; Fort, Yves
Tetrahedron Letters, 2000 , vol. 41, # 16 p. 2881 - 2884
反应条件
sodium t-butanolate; [Pd2(dba)2]; tri-tert-butyl phosphine in o-xylene T=120°C; Yield given. Yields of byproduct given;
参考文献
Nishiyama, Masakazu; Yamamoto, Toshihide; Koie, Yasuyuki
Tetrahedron Letters, 1998 , vol. 39, # 7 p. 617 - 620
反应条件
hydrogenchloride 0.35 h; Irradiation;
参考文献
Jaisinghani, Harsha G.; Chowdhury, Boudhayan Roy; Khadilkar
Synthetic Communications, 1998 , vol. 28, # 7 p. 1175 - 1178
参考文献
Pollard; Wicker
Journal of the American Chemical Society, 1954 , vol. 76, p. 1853
反应条件
potassium carbonate in butan-1-ol 28 h; Reflux;
参考文献
Qu, Zhibo; Chen, Xiaolan; Qu, Lingbo; Yuan, Jinwei; Li, Huina; Zhao, Yufen
Phosphorus, Sulfur and Silicon and the Related Elements, 2010 , vol. 185, # 7 p. 1516 - 1520
参考文献
Korgaonkar; Kulkarni; Samant
Journal of the Indian Chemical Society, 1983 , vol. 60, # 9 p. 874 - 876
反应条件
acetic acid in ethanol
5 h; Heating;
参考文献
Shiozawa; Ichikawa; Komuro; Idzu; Ishikawa; Kurashige; Miyazaki; Yamanaka; Sakamoto
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 2 p. 553 - 563
反应条件
potassium hydroxide in di-isopropyl ether; acetonitrile
参考文献
Rhone-Poulenc Sante
Patent: US4547504 A1, 1985 ;
反应条件
acetic acid in ethanol
24 h; Reflux;
参考文献
PHARMAZZ, INC.; MIDWESTERN UNIVERSITY; GULATI, Anil; LAVHALE, Manish, S.; ANDURKAR, Shridhar, V.
Patent: WO2014/35446 A1, 2014 ;
Location in patent: Paragraph 0063 ;
